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Forkhead box protein
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_3co6| PDB=3co6 | SIZE=400| SCENE= |right|CAPTION=Human FoxO1 complex with DNA, Ca+2 and chloride ions, [[3co6]] }} | {{STRUCTURE_3co6| PDB=3co6 | SIZE=400| SCENE= |right|CAPTION=Human FoxO1 complex with DNA, Ca+2 and chloride ions, [[3co6]] }} | ||
| - | '''Forkhead box proteins''' (FOX) are transcription factors involved in regulation of gene expression. They contain a DNA-binding motif of 80-100 amino acids having a winged-helix shape. For details on individual FOX proteins, see <br /> | + | '''Forkhead box proteins''' (FOX) are transcription factors involved in regulation of gene expression. They contain a DNA-binding motif (DBD) of 80-100 amino acids having a winged-helix shape. For details on individual FOX proteins, see <br /> |
*[[FOXP2]]<br /> | *[[FOXP2]]<br /> | ||
*[[FOXP3]]<br /> | *[[FOXP3]]<br /> | ||
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*FOXO1 | *FOXO1 | ||
| - | **[[3co6]], [[3coa]] – hFOXO1 + DNA – human | + | **[[3co6]], [[3coa]] – hFOXO1 DBD + DNA – human<br /> |
| + | **[[4lg0]] - hFOXO1 DBD + DNA + ETS1<br /> | ||
*FOXO3 | *FOXO3 | ||
| - | **[[2uzk]] – hFOXO3 DNA- | + | **[[2uzk]] – hFOXO3 DBD + DNA<br /> |
| + | **[[2k86]] - hFOXO3 FH domain – NMR<br /> | ||
**[[2lqh]], [[2lqi]] - hFOXO3 transactivation domain + CREB-binding protein – NMR<br /> | **[[2lqh]], [[2lqi]] - hFOXO3 transactivation domain + CREB-binding protein – NMR<br /> | ||
*FOXO4 | *FOXO4 | ||
| - | **[[3l2c]] – hFOXO4 | + | **[[3l2c]] – hFOXO4 DBD + DNA |
*FOXP1 | *FOXP1 | ||
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**[[2kiu]] – hFOXP1 DNA-binding domain (mutant) - NMR | **[[2kiu]] – hFOXP1 DNA-binding domain (mutant) - NMR | ||
| - | * | + | *FOXP2 |
**[[2a07]] – hFOXP2 + DNA<br /> | **[[2a07]] – hFOXP2 + DNA<br /> | ||
| - | **[[2as5]] – hFOXP2 | + | **[[2as5]] – hFOXP2 DBD + nuclear factor of activated T-cell + DNA |
| - | * | + | *FOXP3 |
| - | **[[3qrf]] – hFOXP3 | + | **[[3qrf]] – hFOXP3 DBD + nuclear factor of activated T-cell + DNA<br /> |
| + | **[[4wk8]] – hFOXP3 DBD + DNA <br /> | ||
**[[4i1l]] – mFOXP3 residues 189-276 – mouse<br /> | **[[4i1l]] – mFOXP3 residues 189-276 – mouse<br /> | ||
*FOXK2 | *FOXK2 | ||
| - | **[[2c6y]] – hFOXK2 | + | **[[2c6y]] – hFOXK2 DBD + DNA |
*FOXK1 | *FOXK1 | ||
| - | **[[2a3s]], [[2d2w]] – mFOXK1 | + | **[[2a3s]], [[2d2w]] – mFOXK1 DBD – NMR |
*FOXM1 | *FOXM1 | ||
| - | **[[3g73]] – hFOXM1 | + | **[[3g73]] – hFOXM1 DBD + DNA |
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:30, 5 April 2015
Template:STRUCTURE 3co6
Forkhead box proteins (FOX) are transcription factors involved in regulation of gene expression. They contain a DNA-binding motif (DBD) of 80-100 amino acids having a winged-helix shape. For details on individual FOX proteins, see
See also Transcription and RNA Processing and Neurodevelopmental Disorders.
3D structures of FOX
Updated on 05-April-2015
