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Forkhead box protein

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{{STRUCTURE_3co6| PDB=3co6 | SIZE=400| SCENE= |right|CAPTION=Human FoxO1 complex with DNA, Ca+2 and chloride ions, [[3co6]] }}
{{STRUCTURE_3co6| PDB=3co6 | SIZE=400| SCENE= |right|CAPTION=Human FoxO1 complex with DNA, Ca+2 and chloride ions, [[3co6]] }}
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'''Forkhead box proteins''' (FOX) are transcription factors involved in regulation of gene expression. They contain a DNA-binding motif of 80-100 amino acids having a winged-helix shape. For details on individual FOX proteins, see <br />
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'''Forkhead box proteins''' (FOX) are transcription factors involved in regulation of gene expression. They contain a DNA-binding motif (DBD) of 80-100 amino acids having a winged-helix shape. For details on individual FOX proteins, see <br />
*[[FOXP2]]<br />
*[[FOXP2]]<br />
*[[FOXP3]]<br />
*[[FOXP3]]<br />
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*FOXO1
*FOXO1
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**[[3co6]], [[3coa]] – hFOXO1 + DNA – human
+
**[[3co6]], [[3coa]] – hFOXO1 DBD + DNA – human<br />
 +
**[[4lg0]] - hFOXO1 DBD + DNA + ETS1<br />
*FOXO3
*FOXO3
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**[[2uzk]] – hFOXO3 DNA-binding domain + DNA<br />
+
**[[2uzk]] – hFOXO3 DBD + DNA<br />
 +
**[[2k86]] - hFOXO3 FH domain – NMR<br />
**[[2lqh]], [[2lqi]] - hFOXO3 transactivation domain + CREB-binding protein – NMR<br />
**[[2lqh]], [[2lqi]] - hFOXO3 transactivation domain + CREB-binding protein – NMR<br />
*FOXO4
*FOXO4
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**[[3l2c]] – hFOXO4 DNA-binding domain + DNA
+
**[[3l2c]] – hFOXO4 DBD + DNA
*FOXP1
*FOXP1
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**[[2kiu]] – hFOXP1 DNA-binding domain (mutant) - NMR
**[[2kiu]] – hFOXP1 DNA-binding domain (mutant) - NMR
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*[[FOXP2]]
+
*FOXP2
**[[2a07]] – hFOXP2 + DNA<br />
**[[2a07]] – hFOXP2 + DNA<br />
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**[[2as5]] – hFOXP2 DNA-binding domain + nuclear factor of activated T-cell + DNA
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**[[2as5]] – hFOXP2 DBD + nuclear factor of activated T-cell + DNA
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*[[FOXP3]]
+
*FOXP3
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**[[3qrf]] – hFOXP3 DNA-binding domain + nuclear factor of activated T-cell + DNA<br />
+
**[[3qrf]] – hFOXP3 DBD + nuclear factor of activated T-cell + DNA<br />
 +
**[[4wk8]] – hFOXP3 DBD + DNA <br />
**[[4i1l]] – mFOXP3 residues 189-276 – mouse<br />
**[[4i1l]] – mFOXP3 residues 189-276 – mouse<br />
*FOXK2
*FOXK2
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**[[2c6y]] – hFOXK2 DNA-binding domain + DNA
+
**[[2c6y]] – hFOXK2 DBD + DNA
*FOXK1
*FOXK1
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**[[2a3s]], [[2d2w]] – mFOXK1 DNA-binding domain – NMR
+
**[[2a3s]], [[2d2w]] – mFOXK1 DBD – NMR
*FOXM1
*FOXM1
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**[[3g73]] – hFOXM1 DNA-binding domain + DNA
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**[[3g73]] – hFOXM1 DBD + DNA
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:30, 5 April 2015

Template:STRUCTURE 3co6 Forkhead box proteins (FOX) are transcription factors involved in regulation of gene expression. They contain a DNA-binding motif (DBD) of 80-100 amino acids having a winged-helix shape. For details on individual FOX proteins, see

See also Transcription and RNA Processing and Neurodevelopmental Disorders.

3D structures of FOX

Updated on 05-April-2015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, David Canner

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