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1lrh

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|PDB= 1lrh |SIZE=350|CAPTION= <scene name='initialview01'>1lrh</scene>, resolution 1.9&Aring;
|PDB= 1lrh |SIZE=350|CAPTION= <scene name='initialview01'>1lrh</scene>, resolution 1.9&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=NLA:NAPHTHALEN-1-YL-ACETIC ACID'>NLA</scene>
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NLA:NAPHTHALEN-1-YL-ACETIC+ACID'>NLA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= ABP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4577 Zea mays])
|GENE= ABP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4577 Zea mays])
 +
|DOMAIN=
 +
|RELATEDENTRY=[[1lr5|1LR5]]
 +
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lrh OCA], [http://www.ebi.ac.uk/pdbsum/1lrh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lrh RCSB]</span>
}}
}}
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[[Category: Venis, M.]]
[[Category: Venis, M.]]
[[Category: Woo, E J.]]
[[Category: Woo, E J.]]
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[[Category: NLA]]
 
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[[Category: ZN]]
 
[[Category: beta jellyroll]]
[[Category: beta jellyroll]]
[[Category: double stranded parallel beta helix]]
[[Category: double stranded parallel beta helix]]
[[Category: germin like protein]]
[[Category: germin like protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:34:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:06:23 2008''

Revision as of 19:06, 30 March 2008

Image:1lrh.gif


PDB ID 1lrh

Drag the structure with the mouse to rotate
, resolution 1.9Å
Ligands: , , , ,
Gene: ABP1 (Zea mays)
Related: 1LR5


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal structure of auxin-binding protein 1 in complex with 1-naphthalene acetic acid


Overview

The structure of auxin-binding protein 1 (ABP1) from maize has been determined at 1.9 A resolution, revealing its auxin-binding site. The structure confirms that ABP1 belongs to the ancient and functionally diverse germin/seed storage 7S protein superfamily. The binding pocket of ABP1 is predominantly hydrophobic with a metal ion deep inside the pocket coordinated by three histidines and a glutamate. Auxin binds within this pocket, with its carboxylate binding the zinc and its aromatic ring binding hydrophobic residues including Trp151. There is a single disulfide between Cys2 and Cys155. No conformational rearrangement of ABP1 was observed when auxin bound to the protein in the crystal, but examination of the structure reveals a possible mechanism of signal transduction.

About this Structure

1LRH is a Single protein structure of sequence from Zea mays. Full crystallographic information is available from OCA.

Reference

Crystal structure of auxin-binding protein 1 in complex with auxin., Woo EJ, Marshall J, Bauly J, Chen JG, Venis M, Napier RM, Pickersgill RW, EMBO J. 2002 Jun 17;21(12):2877-85. PMID:12065401

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