1lti
From Proteopedia
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|PDB= 1lti |SIZE=350|CAPTION= <scene name='initialview01'>1lti</scene>, resolution 2.13Å | |PDB= 1lti |SIZE=350|CAPTION= <scene name='initialview01'>1lti</scene>, resolution 2.13Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene> | + | |LIGAND= <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lti OCA], [http://www.ebi.ac.uk/pdbsum/1lti PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lti RCSB]</span> | ||
}} | }} | ||
| Line 24: | Line 27: | ||
[[Category: Akker, F Van Den.]] | [[Category: Akker, F Van Den.]] | ||
[[Category: Hol, W G.J.]] | [[Category: Hol, W G.J.]] | ||
| - | [[Category: GAL]] | ||
[[Category: adp-ribosyl transferase]] | [[Category: adp-ribosyl transferase]] | ||
[[Category: enterotoxin]] | [[Category: enterotoxin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:07:08 2008'' |
Revision as of 19:07, 30 March 2008
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| , resolution 2.13Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN
Overview
Heat-labile enterotoxin (LT) is part of the cholera toxin (CT) family and consists of a catalytic A subunit and a B pentamer that serves to recognize the oligosaccharide part of the GM1 ganglioside receptor. We report here the crystal structure of heat-labile enterotoxin in complex with the disaccharide portion of the Thomsen-Friedenreich (T-antigen) tumor marker. The toxin:carbohydrate complex is determined to 2.13 A resolution, yielding an R-factor of 18.5%. The T-antigen disaccharide, D-Gal-beta 1,3-GalNAc-Ser/Thr, is present in more than 85% of human carcinomas and monitoring its autoimmune response is used for the early detection of tumors. Insight into the molecular recognition of this tumor antigen by sugar binding proteins can benefit the development of a diagnostic tool for human carcinomas as well as a T-antigen directed anticancer drug delivery system.
About this Structure
1LTI is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Tumor marker disaccharide D-Gal-beta 1, 3-GalNAc complexed to heat-labile enterotoxin from Escherichia coli., van den Akker F, Steensma E, Hol WG, Protein Sci. 1996 Jun;5(6):1184-8. PMID:8762150
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