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4qrr

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'''Unreleased structure'''
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==Crystal Structure of HLA B*3501-IPS in complex with a Delta-Beta TCR, clone 12 TCR==
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<StructureSection load='4qrr' size='340' side='right' caption='[[4qrr]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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The entry 4qrr is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4qrr]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QRR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QRR FirstGlance]. <br>
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Authors: Gras, S., Chabrol, E., Rossjohn, J.
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qrp|4qrp]], [[4qrq|4qrq]], [[4qrs|4qrs]], [[4qrt|4qrt]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qrr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qrr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qrr RCSB], [http://www.ebi.ac.uk/pdbsum/4qrr PDBsum]</span></td></tr>
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Description: Crystal Structure of HLA B*3501-IPS in complex with a Delta-Beta TCR, clone 12 TCR
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/1B35_HUMAN 1B35_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. [[http://www.uniprot.org/uniprot/PP65_HCMVT PP65_HCMVT]] Forms part of the matrix of the HCMV virion.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Chabrol, E]]
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[[Category: Gras, S]]
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[[Category: Rossjohn, J]]
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[[Category: Hla b*3501]]
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[[Category: Huamn cmv]]
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[[Category: Immune system]]
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[[Category: T cell]]
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[[Category: Tcr]]

Revision as of 16:23, 10 December 2014

Crystal Structure of HLA B*3501-IPS in complex with a Delta-Beta TCR, clone 12 TCR

4qrr, resolution 3.00Å

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