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4ri8

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'''Unreleased structure'''
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==FAN1 Nuclease bound to 5' phosphorylated p(dG)/3'(dT-dT-dT-dT) double flap DNA==
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<StructureSection load='4ri8' size='340' side='right' caption='[[4ri8]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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The entry 4ri8 is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ri8]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RI8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RI8 FirstGlance]. <br>
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Authors: Pavletich, N.P., Wang, R.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ri9|4ri9]], [[4ria|4ria]], [[4rib|4rib]], [[4ric|4ric]], [[4rid|4rid]]</td></tr>
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Description: FAN1 Nuclease bond to 5' phosphorylated p(dG)1/3' (dT)4 double flap DNA
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ri8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ri8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ri8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ri8 PDBsum]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN]] Karyomegalic interstitial nephritis. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN]] Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhook the ICL by cleaving the lagging-strand template.<ref>PMID:20603015</ref> <ref>PMID:20603016</ref> <ref>PMID:20603073</ref> <ref>PMID:20671156</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Pavletich, N P]]
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[[Category: Wang, R]]
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[[Category: Hydrolase-dna complex]]
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[[Category: Nuclease]]

Revision as of 09:43, 3 December 2014

FAN1 Nuclease bound to 5' phosphorylated p(dG)/3'(dT-dT-dT-dT) double flap DNA

4ri8, resolution 2.90Å

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