Gcn4
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_2dgc| PDB=2dgc | SIZE=400| SCENE= |right|CAPTION=Gcn4 complex with DNA [[2dgc]] }} | {{STRUCTURE_2dgc| PDB=2dgc | SIZE=400| SCENE= |right|CAPTION=Gcn4 complex with DNA [[2dgc]] }} | ||
| - | '''Gcn4''' is a yeast transcriptional activator. It belongs to a large family of eukaryotic transcription factors including Fos, Jun and CREB. All family members have a DNA recognition motif | + | '''Gcn4''' is a yeast transcriptional activator. It belongs to a large family of eukaryotic transcription factors including Fos, Jun and CREB. All family members have a DNA recognition motif consisting of a coiled-coil dimerization element, the leucine-zipper, and an adjoining basic region, which mediates DNA binding. This basic region is largely unstructured in the absence of DNA, addition of DNA containing a Gcn4 binding site induces the transition of this region from unstructured to α-helical. Gcn4-pLI is a 33-residue peptide of the dimerization domain of Gcn4. See also [[Intrinsically Disordered Protein]]. |
== 3D Structures of Gcn4 == | == 3D Structures of Gcn4 == | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *Gcn4 | + | *Gcn4 coiled-coil domain |
| - | **[[2zta]], [[1w5i]], [[2b1f]], [[2b22]], [[2ag3]], | + | **[[2zta]], [[1w5i]], [[2b1f]], [[2b22]], [[2ag3]], [[2r2v]], [[4c46]], [[4hu5]], [[4hu6]] – yGcn4 - yeast <br /> |
**[[2ovn]], [[2l56]] – yGcn4 - NMR<br /> | **[[2ovn]], [[2l56]] – yGcn4 - NMR<br /> | ||
| - | **[[1u2u]] – yGcn4 dimer - NMR<br /> | ||
| - | **[[4dmd]], [[1kd8]], [[1kd9]], [[1kdd]], [[4hu5]], [[4hu6]] – yGcn4 dimer <br /> | ||
| - | **[[4dme]] – yGcn4 trimer <br /> | ||
**[[3ck4]], [[3crp]], [[2ipz]] – yGcn4 tetramer <br /> | **[[3ck4]], [[3crp]], [[2ipz]] – yGcn4 tetramer <br /> | ||
| - | **[[1gcl]], [[1swi]], [[1ce9]], [[1w5g]], [[1w5h]], [[1w5j]], [[1w5k]], [[1w5l]], [[1unt]], [[1unu]], [[1unv]], [[1unw]], [[1unx]], [[1uny]], [[1unz]], [[1uo0]], [[1uo1]], [[1uo2]], [[1uo3]], [[1uo4]], [[1uo5]], [[1u9f]], [[1u9g]], [[1u9h]], [[2bni]], [[2cce]], [[2ccf]], [[2ccn]], [[2ahp]], [[2hy6]], [[3i1g]], [[2wpy]], [[2wpz]], [[2wq0]], [[2wq1]], [[2wq2]], [[2wq3]], [[3k7z]], [[3gjp]], [[3m48]] – yGcn4 (mutant)<br /> | + | **[[1gcl]], [[1swi]], [[1ce9]], [[1w5g]], [[1w5h]], [[1w5j]], [[1w5k]], [[1w5l]], [[1unt]], [[1unu]], [[1unv]], [[1unw]], [[1unx]], [[1uny]], [[1unz]], [[1uo0]], [[1uo1]], [[1uo2]], [[1uo3]], [[1uo4]], [[1uo5]], [[1u9f]], [[1u9g]], [[1u9h]], [[2bni]], [[2cce]], [[2ccf]], [[2ccn]], [[2ahp]], [[2hy6]], [[3i1g]], [[2wpy]], [[2wpz]], [[2wq0]], [[2wq1]], [[2wq2]], [[2wq3]], [[3k7z]], [[3gjp]], [[3m48]], [[4niz]], [[4nj0]], [[4nj1]], [[4nj2]], [[4tl1]] – yGcn4 (mutant)<br /> |
**[[1zii]], [[1zik]], [[1zil]] – yGcn4 dimer (mutant)<br /> | **[[1zii]], [[1zik]], [[1zil]] – yGcn4 dimer (mutant)<br /> | ||
**[[2o7h]], [[1gcm]], [[1zij]], [[1zim]], [[1piq]], [[1ij0]], [[1ij1]], [[1ij2]], [[1ij3]], [[1rb4]], [[1rb5]], [[1rb6]] – yGcn4 trimer (mutant)<br /> | **[[2o7h]], [[1gcm]], [[1zij]], [[1zim]], [[1piq]], [[1ij0]], [[1ij1]], [[1ij2]], [[1ij3]], [[1rb4]], [[1rb5]], [[1rb6]] – yGcn4 trimer (mutant)<br /> | ||
**[[2nrn]] – yGcn4 tetramer (mutant)<br /> | **[[2nrn]] – yGcn4 tetramer (mutant)<br /> | ||
**[[1fmh]] – yGcn4 dimer (mutant) - NMR<br /> | **[[1fmh]] – yGcn4 dimer (mutant) - NMR<br /> | ||
| - | **[[1c94]] – yGcn4 retro<br /> | ||
**[[1ysa]], [[1dgc]], [[2dgc]] – yGcn4 dimer + DNA <br /> | **[[1ysa]], [[1dgc]], [[2dgc]] – yGcn4 dimer + DNA <br /> | ||
| + | |||
| + | *Gcn4-pLI | ||
| + | |||
| + | **[[2ag3]], [[2oxj]], [[2oxk]] – yGcn4-pLI (br /> | ||
| + | **[[1u2u]] – yGcn4-pLI dimer - NMR<br /> | ||
| + | **[[4dmd]], [[1kd8]], [[1kd9]], [[1kdd]] – yGcn4-pLI dimer <br /> | ||
| + | **[[4dme]] – yGcn4-pLI trimer <br /> | ||
| + | **[[1c94]] – yGcn4-pLI retro<br /> | ||
| + | |||
| + | *Gcn4 transcription activation domain | ||
| + | |||
**[[2lpb]] – yGcn4 + mediator of RNA polymerase II<br /> | **[[2lpb]] – yGcn4 + mediator of RNA polymerase II<br /> | ||
Revision as of 09:51, 6 April 2015
Gcn4 is a yeast transcriptional activator. It belongs to a large family of eukaryotic transcription factors including Fos, Jun and CREB. All family members have a DNA recognition motif consisting of a coiled-coil dimerization element, the leucine-zipper, and an adjoining basic region, which mediates DNA binding. This basic region is largely unstructured in the absence of DNA, addition of DNA containing a Gcn4 binding site induces the transition of this region from unstructured to α-helical. Gcn4-pLI is a 33-residue peptide of the dimerization domain of Gcn4. See also Intrinsically Disordered Protein.
3D Structures of Gcn4
Updated on 06-April-2015
