Glycerol kinase
From Proteopedia
(Difference between revisions)
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**[[2d4w]] - GK - ''Cellulomonas''<br /> | **[[2d4w]] - GK - ''Cellulomonas''<br /> | ||
**[[2zf5]] - GK - ''Thermococcus kodakarensis''<br /> | **[[2zf5]] - GK - ''Thermococcus kodakarensis''<br /> | ||
| - | **[[3gg4]] – GK – ''Yersinia pseudotuberculosis'' | + | **[[3gg4]] – GK – ''Yersinia pseudotuberculosis''<br /> |
| + | **[[3wxi]] – TbGK – ''Trypanosoma brucei gambiense''<br /> | ||
*Glycerol kinase binary complex with glycerol | *Glycerol kinase binary complex with glycerol | ||
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**[[4e1j]] – GK + glycerol – ''Sinorhizobium meliloti''<br /> | **[[4e1j]] – GK + glycerol – ''Sinorhizobium meliloti''<br /> | ||
**[[1bu6]], [[3ezw]] - EcGK (mutant) + glycerol<br /> | **[[1bu6]], [[3ezw]] - EcGK (mutant) + glycerol<br /> | ||
| + | **[[3wxk]] – TbGK + glycerol <br /> | ||
*Glycerol kinase ternary complex | *Glycerol kinase ternary complex | ||
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**[[3ge1]] - SaGK + ADP + glycerol<br /> | **[[3ge1]] - SaGK + ADP + glycerol<br /> | ||
**[[3h3o]] - EncGK (mutant) + phosphate + glycerol<br /> | **[[3h3o]] - EncGK (mutant) + phosphate + glycerol<br /> | ||
| - | **[[3h45]] - EncGK (mutant) + phosphate + ethylene glycol | + | **[[3h45]] - EncGK (mutant) + phosphate + ethylene glycol<br /> |
| + | **[[3wxj]] – TbGK + glycerol + G3P<br /> | ||
| + | **[[3wxl]] – TbGK + glycerol + ADP<br /> | ||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 11:01, 8 April 2015
Template:STRUCTURE 1r59
Glycerol kinase (GK) phosphorylates glycerol forming glycerol 3-phosphate (G3P) using Mg-ATP as phosphate source. GK is a key enzyme in glycerol uptake and metabolism. Mutations of GK gene cause GK deficiency syndrome. PK is a multi-subunit allosteric enzyme. Its activity can be inhibited by fructose 1,6-bisphosphate (FBP) and by the glucose-specific phosphocarrier IIA(Glc). PK cofactor is a Zn atom which binds to the dimer.
3D structures of glycerol kinase
Updated on 08-April-2015
