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Granzyme

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<StructureSection load='1fq3' size='400' side='right' caption='Structure of glycosylated human granzyme B dimer complex with sulfate (PDB entry [[1fq3]])' scene=''>
<StructureSection load='1fq3' size='400' side='right' caption='Structure of glycosylated human granzyme B dimer complex with sulfate (PDB entry [[1fq3]])' scene=''>
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'''Granzymes''' (GZM) are serine proteases which induce apoptosis in virus-infected cells.
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'''Granzymes''' (GZM) are serine proteases which induce apoptosis in virus-infected cells<ref>PMID:17158907</ref>.<br />
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*'''Granzyme A and K''' is the most abundant serine protease in killer cells cytotoxic granules <ref>PMID:20536557</ref>.<br />
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*'''Granzyme B and C''' induces cytotoxic T lymphocyte-mediated target cell apoptosis <ref>PMID:12752668</ref>.<br />
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*'''Granzyme H''' helps granzyme B kill adenovirus-infected cells <ref>PMID:17766182</ref>.<br />
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*'''Granzyme M''' induces target cell death, inhibits viral replication and regulates inflammation <ref>PMID:24413154</ref>.<br />
</StructureSection>
</StructureSection>
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**[[2zgj]] – hGZM (mutant) + polypeptide<br />
**[[2zgj]] – hGZM (mutant) + polypeptide<br />
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:35, 16 March 2016

Structure of glycosylated human granzyme B dimer complex with sulfate (PDB entry 1fq3)

Drag the structure with the mouse to rotate

3D structures of granzyme

Updated on 16-March-2016

References

  1. ↑ Bots M, Medema JP. Granzymes at a glance. J Cell Sci. 2006 Dec 15;119(Pt 24):5011-4. PMID:17158907 doi:http://dx.doi.org/10.1242/jcs.03239
  2. ↑ Lieberman J. Granzyme A activates another way to die. Immunol Rev. 2010 May;235(1):93-104. doi: 10.1111/j.0105-2896.2010.00902.x. PMID:20536557 doi:http://dx.doi.org/10.1111/j.0105-2896.2010.00902.x
  3. ↑ Lord SJ, Rajotte RV, Korbutt GS, Bleackley RC. Granzyme B: a natural born killer. Immunol Rev. 2003 Jun;193:31-8. PMID:12752668
  4. ↑ Waterhouse NJ, Trapani JA. H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells. Trends Immunol. 2007 Sep;28(9):373-5. Epub 2007 Sep 4. PMID:17766182 doi:http://dx.doi.org/10.1016/j.it.2007.08.001
  5. ↑ de Poot SA, Bovenschen N. Granzyme M: behind enemy lines. Cell Death Differ. 2014 Mar;21(3):359-68. doi: 10.1038/cdd.2013.189. Epub 2014, Jan 10. PMID:24413154 doi:http://dx.doi.org/10.1038/cdd.2013.189

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