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Hepatocyte growth factor

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<StructureSection load='1shy' size='350' side='right' caption='Structure of human HGF β chain (grey) complex with HGF receptor Sema and ψ domains (green) (PDB entry [[1shy]])' scene=''>
<StructureSection load='1shy' size='350' side='right' caption='Structure of human HGF β chain (grey) complex with HGF receptor Sema and ψ domains (green) (PDB entry [[1shy]])' scene=''>
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'''Hepatocyte growth factor''' (HGF) regulates cell growth, motility and morphogenesis. HGF binds to proto-oncogene c-Met receptor and activates a tyrosine kinase signaling cascade. HGF precursor is cleaved by serine protease to α and β (residues 495-728) chains which form a disulfide bond to produce the active heterodimer. HGF NK1 variant is comprised of residues 28-210 containing the N-terminus and the first kringle domain of HGF. HGF NK2 variant is comprised of residues 28-289 containing the N-terminus and the first 2 kringle domains of HGF.
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'''Hepatocyte growth factor''' (HGF) regulates cell growth, motility and morphogenesis. HGF binds to proto-oncogene c-Met receptor and activates a tyrosine kinase signaling cascade. HGF precursor is cleaved by serine protease to α (69 kD) and β (34 kD) chains which form a disulfide bond to produce the active heterodimer. '''HGF NK1''' variant is comprised of residues 28-210 containing the N-terminus and the first kringle domain of HGF. '''HGF NK2''' variant is comprised of residues 28-289 containing the N-terminus and the first 2 kringle domains of HGF.
</StructureSection>
</StructureSection>
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**[[3sp8]] – hHGF NK2 (mutant) + heparin<br />
**[[3sp8]] – hHGF NK2 (mutant) + heparin<br />
**[[4iua]] – mHGF NK2 (mutant) <br />
**[[4iua]] – mHGF NK2 (mutant) <br />
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*HGF α chain (69 kD)
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**[[4o3t]], [[4o3u]] – hHGF α chain (mutant) + HGF receptor Sema and ψ domains + zymogen activator peptide<br />
*HGF β chain
*HGF β chain

Revision as of 10:04, 20 April 2015

Structure of human HGF β chain (grey) complex with HGF receptor Sema and ψ domains (green) (PDB entry 1shy)

Drag the structure with the mouse to rotate

3D structures of hepatocyte growth factor

Updated on 20-April-2015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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