Histidine triad nucleotide-binding protein
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | '''Histidine triad nucleotide-binding protein''' (HINT) or '''protein kinase C interacting protein''' hydrolyzes purine nucleotide monophosphoamidates and some amino acid-AMPs | + | '''Histidine triad nucleotide-binding protein''' (HINT) or '''protein kinase C interacting protein''' hydrolyzes purine nucleotide monophosphoamidates and some amino acid-AMPs<ref>PMID:23576580</ref>. '''Fragile histidine triad''' (FHIT) cleave diadenosine polyphosphates like ApppA. |
== Disease == | == Disease == | ||
| + | FHIT gene abnormalities are seen in gallbladder carcinoma<ref>PMID:12057912</ref> and lung cancer<ref>PMID:14731325</ref>. | ||
== Relevance == | == Relevance == | ||
| - | + | HINT is a tumor suppressor. FHIT-Ap(n)A complex functions in proapoptotic tumor suppression pathway. FHIT is overexpressed in inflammatory bowel disease<ref>PMID:20083852</ref> and in colorectal cancer<ref>PMID:20083853</ref>. | |
== Structural highlights == | == Structural highlights == | ||
</StructureSection> | </StructureSection> | ||
Revision as of 10:22, 22 March 2016
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3D structures of histidine triad nucleotide-binding protein
Updated on 22-March-2016
References
- ↑ Linde CI, Feng B, Wang JB, Golovina VA. Histidine triad nucleotide-binding protein 1 (HINT1) regulates Ca(2+) signaling in mouse fibroblasts and neuronal cells via store-operated Ca(2+) entry pathway. Am J Physiol Cell Physiol. 2013 Jun 1;304(11):C1098-104. doi:, 10.1152/ajpcell.00073.2013. Epub 2013 Apr 10. PMID:23576580 doi:http://dx.doi.org/10.1152/ajpcell.00073.2013
- ↑ Wistuba II, Ashfaq R, Maitra A, Alvarez H, Riquelme E, Gazdar AF. Fragile histidine triad gene abnormalities in the pathogenesis of gallbladder carcinoma. Am J Pathol. 2002 Jun;160(6):2073-9. PMID:12057912 doi:http://dx.doi.org/10.1016/S0002-9440(10)61157-1
- ↑ Zochbauer-Muller S, Wistuba II, Minna JD, Gazdar AF. Fragile histidine triad (FHIT) gene abnormalities in lung cancer. Clin Lung Cancer. 2000 Nov;2(2):141-5. PMID:14731325
- ↑ Wierzbicki PM, Adrych K, Kartanowicz D, Wypych J, Stanislawowski M, Zwolinska-Wcislo M, Celinski K, Skrodzka D, Godlewski J, Korybalski B, Smoczynski M, Kmiec Z. Overexpression of the fragile histidine triad (FHIT) gene in inflammatory bowel disease. J Physiol Pharmacol. 2009 Oct;60 Suppl 4:57-62. PMID:20083852
- ↑ Wierzbicki PM, Adrych K, Kartanowicz D, Dobrowolski S, Stanislawowski M, Chybicki J, Godlewski J, Korybalski B, Smoczynski M, Kmiec Z. Fragile histidine triad (FHIT) gene is overexpressed in colorectal cancer. J Physiol Pharmacol. 2009 Oct;60 Suppl 4:63-70. PMID:20083853
