Hydroxysteroid dehydrogenase
From Proteopedia
(Difference between revisions)
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**[[3g49]] - gpHSD catalytic domain + inhibitor + NADP<BR /> | **[[3g49]] - gpHSD catalytic domain + inhibitor + NADP<BR /> | ||
| - | **[[1y5r]], [[3gmd]] - mHSD + hydroxysteroid + NADP<BR /> | + | **[[1y5r]], [[3gmd]] - mHSD 1 + hydroxysteroid + NADP<BR /> |
| - | **[[2bel]] - hHSD + hydroxysteroid + NADP<BR /> | + | **[[4k26]] - mHSD 1 + inhibitor + NADP<br /> |
| - | **[[2irw]], [[2ilt]] - hHSD + inhibitor + NADP<BR /> | + | **[[4nmh]] - mHSD 1 (mutant) + inhibitor + NADP<br /> |
| - | **[[2rbe]], [[3byz]], [[3bzu]], [[3ch6]], [[3czr]], [[3d3e]], [[3d4n]], [[3d5q]], [[3ey4]], [[3frj]], [[3hfg]], [[3fco]], [[3h6k]], [[3oq1]], [[3pdj]], [[3tfq]], [[3qqp]] - hHSD (mutant) + inhibitor + NADP<BR /> | + | **[[2bel]] - hHSD 1 + hydroxysteroid + NADP<BR /> |
| + | **[[2irw]], [[2ilt]], [[4bb5]], [[4bb6]] - hHSD 1 + inhibitor + NADP<BR /> | ||
| + | **[[2rbe]], [[3byz]], [[3bzu]], [[3ch6]], [[3czr]], [[3d3e]], [[3d4n]], [[3d5q]], [[3ey4]], [[3frj]], [[3hfg]], [[3fco]], [[3h6k]], [[3oq1]], [[3pdj]], [[3tfq]], [[3qqp]], [[4c7j]], [[4c7k]], [[4p38]] - hHSD 1 (mutant) + inhibitor + NADP<BR /> | ||
*17-β HSD | *17-β HSD | ||
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*''17-β HSD ternary complex'' | *''17-β HSD ternary complex'' | ||
| - | **[[1qyw]], [[1qyx]], [[1fdt]] - hHSD + hydroxysteroid + NADP<BR /> | + | **[[1qyw]], [[1qyx]], [[1fdt]] - hHSD 1 + hydroxysteroid + NADP<BR /> |
| - | **[[1a27]], [[1fdu]] - hHSD (mutant) + hydroxysteroid + NADP<BR /> | + | **[[1a27]], [[1fdu]] - hHSD 1 (mutant) + hydroxysteroid + NADP<BR /> |
| - | **[[3hb5]] - hHSD + inhibitor + NADP<BR /> | + | **[[3hb5]] - hHSD 1 + inhibitor + NADP<BR /> |
| + | **[[4hfr]], [[4hx5]], [[4iju]], [[4ijv]], [[4ijw]], [[4k1l]] - hHSD 1 (mutant) + inhibitor + NADP<br /> | ||
| + | **[[4cql]] - hHSD 8 + carbonyl reductase + NAD<br /> | ||
| + | **[[4cqm]] - hHSD 8 + carbonyl reductase + NADP<br /> | ||
**[[3qwi]], [[3qwh]] - ClHSD + hydroxysteroid + NADP<BR /> | **[[3qwi]], [[3qwh]] - ClHSD + hydroxysteroid + NADP<BR /> | ||
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**[[2hsd]] – SeHSD – ''Streptomyces exfoliates''<BR /> | **[[2hsd]] – SeHSD – ''Streptomyces exfoliates''<BR /> | ||
**[[1hdc]] – SeHSD + inhibitor | **[[1hdc]] – SeHSD + inhibitor | ||
| + | |||
| + | *Carbonyl reductase/20-β HSD | ||
| + | |||
| + | **[[1n5d]] - HSD + NADP – pig<br /> | ||
*3-β/17-β HSD | *3-β/17-β HSD | ||
Revision as of 08:54, 22 April 2015
Template:STRUCTURE 1lwi
Hydroxysteroid dehydrogenase (HSD) catalyzes the dehydrogenation of hydroxysteroids. HSD is classified according to the number of carbon it is acting on.
- 3-α HSD catalyzes the conversion of androsterone to 5α-androstane-3, 17-dione and 17-α estradiol to estrone. 3-α HSD (also named 17-α HSD) is a bile acid-metabolizing enzyme.
- 7-α HSD is involved in the dehydrogenation of cholanate compounds and is a bile acid-inducible enzyme.
- 20-α HSD is involved in the control of progesterone level in pregnancy of mice.
- 11-β HSD converts 11-keto products like cortisone to cortisol.
- 17-β HSD is involved in the conversion of androstenedione to testosterone.
- 3-β/17-β HSD catalyzes the reversible dehydrogenation of steroid compounds at position 3 and 17.
NAD and NADP are cofactors of HSD.
3D structures of hydroxysteroid dehydrogenase
Updated on 22-April-2015
For 3-α HSD type 2 see Prostaglandin F synthase
For 17-β HSD type 5 see Prostaglandin F synthase
