Importin

(Difference between revisions)

Revision as of 07:31, 1 January 2015

Structure of yeast importin α NLS-binding domain (grey) complex with nucleoplasmin peptide (green) (PDB code 1ee5).

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Updated on 01-January-2015

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 == Function ==
-'''Importins''' (IPO) mediate the import of cellular proteins into the nucleus by binding to the nuclear localization signal (NLS).  IPO has 2 subunits: α and β.  IPO-α is an adaptor protein which binds the NLS.  Proteins can contain one or two NLS motifs.  IPO-α contains several armadillo repeats with two NLS-binding sites and an IPO-β binding site (IBB).  IPO-β contains 19 HEAT repeats.  Many nuclear proteins contain Phe-Gly sequences which can bind to HEAT repeats and thus be transported.
+'''Importins''' (IPO) mediate the import of cellular proteins into the nucleus by binding to the nuclear localization signal (NLS).  IPO has 2 subunits: α and β.  IPO-α is an adaptor protein which binds the NLS.  Proteins can contain one or two NLS motifs.  IPO-α contains several armadillo repeats with two NLS-binding sites and an IPO-β binding site (IBB).  IPO-β contains 19 HEAT repeats.  Many nuclear proteins contain Phe-Gly sequences which can bind to HEAT repeats and thus be transported.  See also [[Protein Transport Membrane Protein]].
 == Disease ==