1m55
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1m55 |SIZE=350|CAPTION= <scene name='initialview01'>1m55</scene>, resolution 1.40Å | |PDB= 1m55 |SIZE=350|CAPTION= <scene name='initialview01'>1m55</scene>, resolution 1.40Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m55 OCA], [http://www.ebi.ac.uk/pdbsum/1m55 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m55 RCSB]</span> | ||
}} | }} | ||
| Line 26: | Line 29: | ||
[[Category: Kotin, R M.]] | [[Category: Kotin, R M.]] | ||
[[Category: Ronning, D R.]] | [[Category: Ronning, D R.]] | ||
| - | [[Category: CL]] | ||
| - | [[Category: ZN]] | ||
[[Category: adeno-associated virus]] | [[Category: adeno-associated virus]] | ||
[[Category: endonuclease]] | [[Category: endonuclease]] | ||
| Line 33: | Line 34: | ||
[[Category: rolling circle replication]] | [[Category: rolling circle replication]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:11:26 2008'' |
Revision as of 19:11, 30 March 2008
| |||||||
| , resolution 1.40Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Catalytic domain of the Adeno Associated Virus type 5 Rep protein
Overview
Adeno-associated virus (AAV), unique among animal viruses in its ability to integrate into a specific chromosomal location, is a promising vector for human gene therapy. AAV Replication (Rep) protein is essential for viral replication and integration, and its amino terminal domain possesses site-specific DNA binding and endonuclease activities required for replication initiation and integration. This domain displays a novel endonuclease fold and demonstrates an unexpected structural relationship to other viral origin binding proteins such as the papillomavirus E1 protein and the SV40 T antigen. The active site, located at the bottom of a positively charged cleft, is formed by the spatial convergence of a divalent metal ion and two conserved sequence motifs that define the rolling circle replication superfamily.
About this Structure
1M55 is a Single protein structure of sequence from Adeno-associated virus - 5. Full crystallographic information is available from OCA.
Reference
Structural unity among viral origin binding proteins: crystal structure of the nuclease domain of adeno-associated virus Rep., Hickman AB, Ronning DR, Kotin RM, Dyda F, Mol Cell. 2002 Aug;10(2):327-37. PMID:12191478
Page seeded by OCA on Sun Mar 30 22:11:26 2008
