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Interleukin receptor

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{{STRUCTURE_2b5i| PDB=2b5i | SIZE=400| SCENE= |right|CAPTION=Glycosylated interleukin-2 receptor α (yellow), β (green), γ (pink) chains complex with interleukin-2 (grey), [[2b5i]] }}
{{STRUCTURE_2b5i| PDB=2b5i | SIZE=400| SCENE= |right|CAPTION=Glycosylated interleukin-2 receptor α (yellow), β (green), γ (pink) chains complex with interleukin-2 (grey), [[2b5i]] }}
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'''Interleukin receptors''' (ILR) are cytokine receptor which are classified into type I, type II and . '''ILR type I''' are cell surface receptors which recognize cytokines with four α-helical strands. '''ILR type II''' are similar to type I but lack the former’s signature sequence: WXSWS. Interleukin-1 receptor belongs to the ILR of immunoglobulin family. IL1R contains two types. Type I (IL1R1) binds interleukin-1 transmitting its inflammatory effect. Interleukin-1 receptor type II (IL1R2) suppresses interleukin-1 activity. Another suppressor of IL1R activity is the interleukin-1 receptor antagonist (IL1R1A).
+
'''Interleukin receptors''' (ILR) are cytokine receptor which are classified into type I, type II and others. '''ILR type I''' are cell surface receptors which recognize cytokines with four α-helical strands. '''ILR type II''' are similar to type I but lack the former’s signature sequence: WXSWS. Interleukin-1 receptor belongs to the ILR of immunoglobulin family. IL1R contains two types. Type I (IL1R1) binds interleukin-1 (IL1) transmitting its inflammatory effect. Interleukin-1 receptor type II (IL1R2) suppresses IL1 activity. Another suppressor of IL1R activity is the interleukin-1 receptor antagonist (IL1R1A).
==3D structures of interleukin receptor==
==3D structures of interleukin receptor==
Line 11: Line 11:
*Interleukin-2 receptor
*Interleukin-2 receptor
-
**[[1z92]] – hIL2R α subunit + interleukin-2<br />
+
**[[1z92]] – hIL2R α subunit + IL2 - human<br />
-
**[[2b5i]] - hIL2R α+β+γ subunits + interleukin-2<br />
+
**[[2b5i]] - hIL2R α+β+γ subunits + IL2<br />
-
**[[3qaz]] - hIL2R β+γ subunits + interleukin-2<br />
+
**[[3qaz]] - hIL2R β+γ subunits + IL2<br />
-
**[[2erj]] - hIL2R α (mutant)+β+γ (mutant) subunits + interleukin-2 (mutant)<br />
+
**[[2erj]] - hIL2R α (mutant)+β+γ (mutant) subunits + IL2 (mutant)<br />
-
**[[3qb7]] - hIL2R γ (mutant) subunit + interleukin-2<br />
+
**[[3qb7]] - hIL2R γ (mutant) subunit + IL2<br />
**[[3iu3]], [[3nfp]] - hIL2R α subunit + antibody
**[[3iu3]], [[3nfp]] - hIL2R α subunit + antibody
 +
 +
*Interleukin-3 receptor
 +
 +
**[[4qqv]] - mIL6R β subunit (mutant)<br />
 +
**[[4jzj]] – hIL3R α subunit + antibody
*Interleukin-4 receptor
*Interleukin-4 receptor
-
**[[1iar]] - hIL4R α (mutant) subunit + interleukin-4<br />
+
**[[1iar]] - hIL4R α (mutant) subunit + IL4<br />
-
**[[3bpl]] - hIL4R α + γ subunits + interleukin-4<br />
+
**[[3bpl]] - hIL4R α + γ subunits + IL4<br />
-
**[[3bpn]] - hIL4R α subunit + hIL13R α subunit + interleukin-4<br />
+
**[[3bpn]] - hIL4R α subunit + hIL13R α subunit + IL4<br />
-
**[[3bpo]] - hIL4R α subunit + hIL13R α subunit + interleukin-13
+
**[[3bpo]] - hIL4R α subunit + hIL13R α subunit + IL13
*Interleukin-5 receptor
*Interleukin-5 receptor
-
**[[3qt2]] – hIL5R α (mutant) subunit + interleukin-5<br />
+
**[[3qt2]] – hIL5R α (mutant) subunit + IL5<br />
-
**[[3va2]] - hIL5R α subunit + interleukin-5<br />
+
**[[3va2]] - hIL5R α subunit + IL5<br />
*Interleukin-6 receptor or gp130
*Interleukin-6 receptor or gp130
-
**[[1i1r]] – hIL6R β subunit + interleukin-6 homolog<br />
+
**[[1i1r]] – hIL6R β subunit + IL6 homolog<br />
**[[1pvh]] - hIL6R β subunit + leukemia inhILbitory factor<br />
**[[1pvh]] - hIL6R β subunit + leukemia inhILbitory factor<br />
**[[2hmh]] - mI6R β subunit + suppressor of cytokine signaling 3 – mouse<br />
**[[2hmh]] - mI6R β subunit + suppressor of cytokine signaling 3 – mouse<br />
Line 39: Line 44:
**[[1n26]] - hIL6R α subunit<br />
**[[1n26]] - hIL6R α subunit<br />
**[[2arw]] - hIL6R α subunit - NMR<br />
**[[2arw]] - hIL6R α subunit - NMR<br />
-
**[[1p9m]] - hIL6R α + β subunits + interleukin-6
+
**[[1p9m]] - hIL6R α + β subunits + IL6
*Interleukin-7 receptor
*Interleukin-7 receptor
**[[3up1]] - hIL7R α subunit<br />
**[[3up1]] - hIL7R α subunit<br />
-
**[[3di2]], [[3di3]] – hIL7R α (mutant) subunit + interleukin-7 (mutant)
+
**[[3di2]], [[3di3]] – hIL7R α (mutant) subunit + IL7 (mutant)<br />
 +
**[[4nn5]], [[4nn6]], [[4nn7]] - mIL7R α subunit + thymic stromal lymphopoietin + cytokine receptor-like factor 2<br />
*Interleukin-13 receptor
*Interleukin-13 receptor
-
**[[3lb6]] - hIL13R α2 (mutant) subunit + interleukin-13<br />
+
**[[3lb6]] - hIL13R α2 (mutant) subunit + IL13<br />
**[[4hwb]] - hIL13R α1 subunit + antibody<br />
**[[4hwb]] - hIL13R α1 subunit + antibody<br />
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**[[2ers]] - hIL15R α subunit sushIL domain – NMR<br />
**[[2ers]] - hIL15R α subunit sushIL domain – NMR<br />
-
**[[2z3q]], [[2z3r]], [[2psm]] - hIL15R α subunit + interleukin-15<br />
+
**[[2z3q]], [[2z3r]], [[2psm]] - hIL15R α subunit + IL15<br />
-
**[[4gs7]] - hIL15R α subunit + interleukin-15 + hIL2R β,γ subunits<br />
+
**[[4gs7]] - hIL15R α subunit + IL15 + hIL2R β,γ subunits<br />
*Interleukin-17 receptor
*Interleukin-17 receptor
-
**[[3jvf]] - hIL17RA extracellular domain + interleukin-17F<br />
+
**[[4nux]] - hIL17RA SEFIR domain<br />
-
**[[4hsa]] - hIL17RA (mutant) + interleukin-17A<br />
+
**[[3jvf]] - hIL17RA extracellular domain + IL17F<br />
 +
**[[4hsa]] - hIL17RA (mutant) + IL17A<br />
**[[3vbc]] – mIL17RB<br />
**[[3vbc]] – mIL17RB<br />
 +
 +
*Interleukin-18 receptor
 +
 +
**[[3wo3]], [[4r6u]] - hIL18 receptor + hIL18 <br />
 +
**[[3wo4]] - hIL18 receptor + hIL18 + IL18 receptor accessory protein<br />
*Interleukin-21 receptor
*Interleukin-21 receptor
-
**[[3tgx]] – hIL21R extracellular domain (mutant) + interleukin-21
+
**[[4nzd]] – hIL21R<br />
 +
**[[3tgx]] – hIL21R extracellular domain (mutant) + IL21
*'''Interleukin receptor type II'''
*'''Interleukin receptor type II'''
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*Interleukin-10 receptor
*Interleukin-10 receptor
-
**[[1j7v]] – hIL10R α (mutant) subunit + interleukin-10<br />
+
**[[1j7v]] – hIL10R α (mutant) subunit + IL10<br />
-
**[[1lqs]], [[1y6m]], [[1y6n]] - hIL10R α (mutant) subunit + interleukin-10 homolog<br />
+
**[[1lqs]], [[1y6m]], [[1y6n]] - hIL10R α (mutant) subunit + IL10 homolog<br />
-
**[[1y6k ]]- hIL10R α (mutant) subunit + interleukin-10<br />
+
**[[1y6k ]]- hIL10R α (mutant) subunit + IL10<br />
**[[3lqm]] - hIL10R β (mutant) subunit
**[[3lqm]] - hIL10R β (mutant) subunit
*Interleukin-20 receptor
*Interleukin-20 receptor
-
**[[4doh]] - hIL20R α,β subunit + interleukin-20<br />
+
**[[4doh]] - hIL20R α,β subunit + IL20<br />
*Interleukin-22 receptor
*Interleukin-22 receptor
-
**[[3g9v]] - hIL22R α subunit + interleukin-22<br />
+
**[[3g9v]] - hIL22R α subunit + IL22<br />
-
**[[3dgc]] – hIL22R α (mutant) subunit + interleukin-22<br />
+
**[[3dgc]] – hIL22R α (mutant) subunit + IL22<br />
-
**[[3dlq]] - hIL22R α (mutant) subunit + interleukin-2 (mutant)
+
**[[3dlq]] - hIL22R α (mutant) subunit + IL2 (mutant)
*Interleukin-28 receptor
*Interleukin-28 receptor
-
**[[3og4]], [[3og6]] - hIL28R α subunit + interleukin-29<br />
+
**[[3og4]], [[3og6]] - hIL28R α subunit + IL29<br />
*'''Interleukin receptor of immunoglobulin family'''
*'''Interleukin receptor of immunoglobulin family'''
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*Interleukin-1 receptor (CD121a, CD121b)
*Interleukin-1 receptor (CD121a, CD121b)
-
**[[1itb]] – hI1R1 extracellular domain + interleukin-1 β – human<br />
+
**[[1itb]] – hI1R1 extracellular domain + IL1 β <br />
**[[1ira]]- hI1R1 extracellular domain + I1R1A<br />
**[[1ira]]- hI1R1 extracellular domain + I1R1A<br />
**[[1g0y]] - hI1R1 extracellular domain + I1R1A peptide<br />
**[[1g0y]] - hI1R1 extracellular domain + I1R1A peptide<br />
-
**[[3o4o]] - hI1R2 + interleukin-1 β<br />
+
**[[3o4o]] - hI1R2 + IL1 β<br />
-
**[[4dep]] – hIL1R1 extracellular domain + interleukin-1 β + + interleukin-1 accessory protein<br />
+
**[[4dep]] – hIL1R1 extracellular domain + IL1 β + + IL1 accessory protein<br />
**[[4gaf]] – hIL1R1 extracellular domain + IL1β/IL1RA <br />
**[[4gaf]] – hIL1R1 extracellular domain + IL1β/IL1RA <br />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:14, 28 April 2015

Template:STRUCTURE 2b5i Interleukin receptors (ILR) are cytokine receptor which are classified into type I, type II and others. ILR type I are cell surface receptors which recognize cytokines with four α-helical strands. ILR type II are similar to type I but lack the former’s signature sequence: WXSWS. Interleukin-1 receptor belongs to the ILR of immunoglobulin family. IL1R contains two types. Type I (IL1R1) binds interleukin-1 (IL1) transmitting its inflammatory effect. Interleukin-1 receptor type II (IL1R2) suppresses IL1 activity. Another suppressor of IL1R activity is the interleukin-1 receptor antagonist (IL1R1A).

3D structures of interleukin receptor

Updated on 28-April-2015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

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