This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Isopenicillin N synthase
From Proteopedia
| Line 11: | Line 11: | ||
**[[1bk0]] - AnIPNS + ACV – ''Aspergillus nidulans''<br /> | **[[1bk0]] - AnIPNS + ACV – ''Aspergillus nidulans''<br /> | ||
**[[2bjs]] - AnIPNS (mutant) + ACV<br /> | **[[2bjs]] - AnIPNS (mutant) + ACV<br /> | ||
| - | **[[1qiq]], [[1qjf]], [[1hb1]], [[1hb2]], [[1hb3]], [[1hb4]], [[1odm]], [[1odn]], [[1oc1]], [[1uzw]], [[1w03]], [[1w05]], [[2bu9]], [[1w3v]], [[1w3x]], [[2ivi]], [[2ivj]], [[2vau]], [[2vbb]], [[2vbd]], [[2vbp]], [[2vcm]], [[2ve1]], [[2wo7]], [[2y6f]], [[2y60]], [[2y86]] - AnIPNS + ACV derivative<br /> | + | **[[1qiq]], [[1qjf]], [[1hb1]], [[1hb2]], [[1hb3]], [[1hb4]], [[1odm]], [[1odn]], [[1oc1]], [[1uzw]], [[1w03]], [[1w05]], [[2bu9]], [[1w3v]], [[1w3x]], [[2ivi]], [[2ivj]], [[2vau]], [[2vbb]], [[2vbd]], [[2vbp]], [[2vcm]], [[2ve1]], [[2wo7]], [[2y6f]], [[2y60]], [[2y86]], [[4bb3]] - AnIPNS + ACV derivative<br /> |
**[[2jb4]] - AnIPNS + cyclobutanone analog<br /> | **[[2jb4]] - AnIPNS + cyclobutanone analog<br /> | ||
**[[1qje]] - AnIPNS + IPN + ACV<br /> | **[[1qje]] - AnIPNS + IPN + ACV<br /> | ||
**[[1blz]] - AnIPNS + NO + ACV<br /> | **[[1blz]] - AnIPNS + NO + ACV<br /> | ||
| - | **[[1obn]], [[1w04]], [[1w06]] - AnIPNS + hydroxylamine + ACV derivative | + | **[[1obn]], [[1w04]], [[1w06]] - AnIPNS + hydroxylamine + ACV derivative<br /> |
| + | **[[3zku]], [[3zky]], [[3zoi]], [[4bb3]] - IPNS + ACV derivative – ''Emericella nidulans''<br /> | ||
*Mn containing IPNS | *Mn containing IPNS | ||
Revision as of 08:58, 30 April 2015
Isopenicillin N synthase (IPNS) is an iron-dependent enzyme which catalyzes the formation of isopenicillin N (IPN) from the tripeptide aminoadipoyl-cysteine-valine (ACV). IPNS participates in the biosynthesis of penicillin and cephalosporin antibiotics. The active site of IPNS contains an Fe atom. The reaction involves the reduction of O2 molecule to H2O.
3D structures of isopenicillin N synthase
Updated on 30-April-2015
