Mannose-binding protein
From Proteopedia
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| - | {{STRUCTURE_1kzb| PDB=1kzb | SIZE=400| SCENE= |right|CAPTION=Rat mannose-binding protein fragment complex with mannose and Ca+2 ion, [[1kzb]] }} | + | {{STRUCTURE_1kzb| PDB=1kzb | SIZE=400| SCENE= |right|CAPTION=Rat mannose-binding protein fragment complex with mannose (stick model) and Ca+2 ion, [[1kzb]] }} |
| - | + | == Function == | |
| - | + | '''Mannose-binding protein''' (MBL) is a lectin essential to innate immunity. MBL recognizes carbohydrate patterns like mannose or glucose located on the surface of microorganisms like bacteria, viruses and fungi. MBL binds to the microorganism and the activation of the lectin pathway ensues. MBL binds to apoptotic and senescent cells and enhances their engulfment by phagocytes. In the blood, MBL is bound to MBL-associated serine protease (MASP-2). Upon binding of MBL to a target mannose, the MASP initiates the complement cascade resulting in lysis of the pathogen<ref>PMID:8528769</ref>. | |
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| - | + | == Structural highlights == | |
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| - | '''Mannose-binding protein''' (MBL) is a lectin essential to innate immunity. MBL recognizes carbohydrate patterns like mannose or glucose located on the surface of microorganisms like bacteria, viruses and fungi. MBL binds to the microorganism and the activation of the lectin pathway ensues. MBL binds to apoptotic and senescent cells and enhances their engulfment by phagocytes. In the blood, MBL is bound to MBL-associated serine protease (MASP-2). Upon binding of MBL to a target mannose, the MASP initiates the complement cascade resulting in lysis of the pathogen. | + | |
==3D structures of mannose-binding protein== | ==3D structures of mannose-binding protein== | ||
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**[[1kzb]], [[1kzc]] - rMBL fragment + mannose | **[[1kzb]], [[1kzc]] - rMBL fragment + mannose | ||
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| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:01, 18 April 2016
Contents |
Function
Mannose-binding protein (MBL) is a lectin essential to innate immunity. MBL recognizes carbohydrate patterns like mannose or glucose located on the surface of microorganisms like bacteria, viruses and fungi. MBL binds to the microorganism and the activation of the lectin pathway ensues. MBL binds to apoptotic and senescent cells and enhances their engulfment by phagocytes. In the blood, MBL is bound to MBL-associated serine protease (MASP-2). Upon binding of MBL to a target mannose, the MASP initiates the complement cascade resulting in lysis of the pathogen[1].
Structural highlights
3D structures of mannose-binding protein
Updated on 18-April-2016
