Mitogen-activated protein kinase kinase

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[[Image:3e8n.png|left|thumb|300px|Crystal Structure of the Mitogen-activated protein kinase kinase, [[3e8n]]]]
 
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{{STRUCTURE_1sko| right| PDB=1sko | SCENE= |CAPTION=Mitogen-activated protein kinase kinase (grey) complex with late endosomal/lysosomal MP1 interacting protein (green), [[1sko]] }}
 
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<StructureSection load='3os3' size='350' side='right' caption='Human α-defensin 1 (PDB entry [[2pm4]])' scene=''>
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== Function ==
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[[Mitogen-activated protein kinase kinase]] (MAP2K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP2K is part of the MAPK cascade which consists also of [[Mitogen-activated protein kinase|MAPK]] and [[Mitogen-activated protein kinase kinase kinase|MAP3K]] which are activated by phosphorylation. '''MAP2K''' activates [[Mitogen-activated protein kinase|MAPK]]<ref>PMID:9528964</ref>.
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== Relevance ==
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MAP2K is activated in melanoma and its inhibitors are tested as therapeutical agents<ref>PMID:22805292</ref>.
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[[Mitogen-activated protein kinase kinase]] (MAP2K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP2K is part of the MAPK cascade which consists also of [[Mitogen-activated protein kinase|MAPK]] and [[Mitogen-activated protein kinase kinase kinase|MAP3K]] which are activated by phosphorylation. '''MAP2K''' activates [[Mitogen-activated protein kinase|MAPK]].
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== 3D Structures of Mitogen-activated protein kinase kinase ==
== 3D Structures of Mitogen-activated protein kinase kinase ==
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**[[2dyl]] – hMAP2K7 kinase domain (mutant)<br />
**[[2dyl]] – hMAP2K7 kinase domain (mutant)<br />
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:09, 28 April 2016

Human α-defensin 1 (PDB entry 2pm4)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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