Muconate cycloisomerase
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_3fyy| PDB=3fyy | SIZE=400| SCENE= |right|CAPTION=Muconate cycloisomerase dimer complex with Mg+2 ion (green), [[3fyy]] }} | {{STRUCTURE_3fyy| PDB=3fyy | SIZE=400| SCENE= |right|CAPTION=Muconate cycloisomerase dimer complex with Mg+2 ion (green), [[3fyy]] }} | ||
| - | '''Muconate cycloisomerase''' (MCI) catalyzes the formation of muconolactone from cis, cis-muconate. It is part of the B-ketoadipate pathway in the metabolism of aromatic compounds. | + | '''Muconate cycloisomerase''' (MCI) catalyzes the formation of muconolactone from ''cis,cis''-muconate. It is part of the B-ketoadipate pathway in the metabolism of aromatic compounds<ref>PMID:9726873</ref>. MCI breaks down lignin-derived catechol and protocatechuate. |
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| + | *Chloromuconate cycloisomerase catalyzes the reversible conversion of 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate to ''cis,cis''-butadiene-1,2,4-tricarboxylate <ref>PMID:7305906</ref>.<br /> | ||
| + | *3-carboxy-''cis,cis''-muconate cycloisomerase catalyzes the reversible conversion of 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate to 3-chloro-''cis,cis''-muconate<ref>PMID:5916392</ref>.<br /> | ||
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== 3D Structures of muconate cycloisomerase == | == 3D Structures of muconate cycloisomerase == | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *''' | + | *'''Chloro-MCI''' |
**[[2chr]] – MCI – ''Cupriavidsua necator''<br /> | **[[2chr]] – MCI – ''Cupriavidsua necator''<br /> | ||
**[[1nu5]] - MCI – ''Pseudomonas'' | **[[1nu5]] - MCI – ''Pseudomonas'' | ||
| - | *''' | + | *'''MCI''' |
**[[1muc]], [[1bkh]] – PbMCI – ''Pseudomonas putida''<br /> | **[[1muc]], [[1bkh]] – PbMCI – ''Pseudomonas putida''<br /> | ||
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**[[3dg3]] – MsMCI - ''Mycobacterium smegmatis'' | **[[3dg3]] – MsMCI - ''Mycobacterium smegmatis'' | ||
| - | * | + | *MCI complexes |
**[[3es7]], [[3es8]] – OiMCI + Mg + malate<br /> | **[[3es7]], [[3es8]] – OiMCI + Mg + malate<br /> | ||
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**[[3rit]] - MCI + Mg + dipeptide – ''Methylococcus capsulatus'' | **[[3rit]] - MCI + Mg + dipeptide – ''Methylococcus capsulatus'' | ||
}} | }} | ||
| + | <references/> | ||
| + | [[Category:Topic Page]] | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:55, 1 May 2016
Muconate cycloisomerase (MCI) catalyzes the formation of muconolactone from cis,cis-muconate. It is part of the B-ketoadipate pathway in the metabolism of aromatic compounds[1]. MCI breaks down lignin-derived catechol and protocatechuate.
- Chloromuconate cycloisomerase catalyzes the reversible conversion of 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate to cis,cis-butadiene-1,2,4-tricarboxylate [2].
- 3-carboxy-cis,cis-muconate cycloisomerase catalyzes the reversible conversion of 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate to 3-chloro-cis,cis-muconate[3].
3D Structures of muconate cycloisomerase
Updated on 01-May-2016
- ↑ Vollmer MD, Hoier H, Hecht HJ, Schell U, Groning J, Goldman A, Schlomann M. Substrate specificity of and product formation by muconate cycloisomerases: an analysis of wild-type enzymes and engineered variants. Appl Environ Microbiol. 1998 Sep;64(9):3290-9. PMID:9726873
- ↑ Schmidt E, Knackmuss HJ. Chemical structure and biodegradability of halogenated aromatic compounds. Conversion of chlorinated muconic acids into maleoylacetic acid. Biochem J. 1980 Oct 15;192(1):339-47. PMID:7305906
- ↑ Ornston LN. The conversion of catechol and protocatechuate to beta-ketoadipate by Pseudomonas putida. II. Enzymes of the protocatechuate pathway. J Biol Chem. 1966 Aug 25;241(16):3787-94. PMID:5916392
