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Nitroreductase
From Proteopedia
(Difference between revisions)
| Line 27: | Line 27: | ||
**[[3hzn]] – NR – ''Salmonella typhimurium''<br /> | **[[3hzn]] – NR – ''Salmonella typhimurium''<br /> | ||
**[[3k6h]] – NR – ''Agrobacterium tumefaciens''<br /> | **[[3k6h]] – NR – ''Agrobacterium tumefaciens''<br /> | ||
| - | **[[2wqf]] – NR – ''Lactococcus lactis''<br /> | ||
**[[2wzv]], [[2ymv]] – MsNR – ''Mycobacterium smegmatis''<br /> | **[[2wzv]], [[2ymv]] – MsNR – ''Mycobacterium smegmatis''<br /> | ||
**[[3of4]] – NR FMN/FAD – ''Idiomarina loihiensis''<br /> | **[[3of4]] – NR FMN/FAD – ''Idiomarina loihiensis''<br /> | ||
| Line 34: | Line 33: | ||
**[[3qdl]] – NR – ''Helicobacter pylori''<br /> | **[[3qdl]] – NR – ''Helicobacter pylori''<br /> | ||
**[[3r5l]], [[3r5p]] - MtNR – ''Mycobacterium tuberculosis''<br /> | **[[3r5l]], [[3r5p]] - MtNR – ''Mycobacterium tuberculosis''<br /> | ||
| - | **[[3r5r]], [[3r5w]] – MtNR F420 | + | **[[3r5r]], [[3r5w]] – MtNR F420<br /> |
| + | **[[3ge6]] – NR – ''Exiguobacterium sibiricum''<br /> | ||
| + | **[[4dn2]] – NR – ''Geobacter metallireducens''<br /> | ||
| + | |||
| + | *Copper-induced nitroreductase | ||
| + | |||
| + | **[[2wqf]] – LlNR – ''Lactococcus lactis''<br /> | ||
| + | **[[4bn6]] – LlNR + chloramphenicol<br /> | ||
| + | **[[4bn7]], [[4bn8]] – LlNR + phenol derivative<br /> | ||
| + | **[[4bn9]] – LlNR + nicotinic acid<br /> | ||
| + | **[[4bnb]] – LlNR + nitroquinoline<br /> | ||
*Nitroreductase binary complex | *Nitroreductase binary complex | ||
Revision as of 06:56, 7 May 2015
Nitroreductase (NR) is involved in the reduction of nitrogen-containing compounds including those containing NO2 group. The NO2 group is reduced to hydroxylamine. NR use FMN as cofactor. Among NRs are the oxygen-insensitive NAD(P)H NR and NADH dehydrogenase. The NR is of special interest due to its potential use as activator of prodrugs in cancer therapy.
3D structures of nitroreductase
Updated on 07-May-2015
