Penicillin acylase
From Proteopedia
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{{STRUCTURE_1fxv| PDB=1fxv | SIZE=400| SCENE= |right|CAPTION=''E. coli'' penicillin acylase small α subunit (grey) and large β subunit (green) complex with penicillin and Ca+2 ion (green), [[1fxv]] }} | {{STRUCTURE_1fxv| PDB=1fxv | SIZE=400| SCENE= |right|CAPTION=''E. coli'' penicillin acylase small α subunit (grey) and large β subunit (green) complex with penicillin and Ca+2 ion (green), [[1fxv]] }} | ||
| + | == Function == | ||
| + | '''Penicillin acylase''' (PAH) catalyzes the conversion of penicillin to 6-amino-penicillanate and phenylacetate (PA). PAH contains 2 non-identical subunits. The larger β subunit contains a phenylmethylsulfonyl residue which is required for enzymatic activity. PAH participates in penicillin and cephalosporin biosynthesis. | ||
| - | + | == Relevance == | |
| + | PAH is used commercially for production of semi-synthetic penicillins. | ||
==3D structures of penicillin acylase== | ==3D structures of penicillin acylase== | ||
Revision as of 10:28, 15 June 2016
Function
Penicillin acylase (PAH) catalyzes the conversion of penicillin to 6-amino-penicillanate and phenylacetate (PA). PAH contains 2 non-identical subunits. The larger β subunit contains a phenylmethylsulfonyl residue which is required for enzymatic activity. PAH participates in penicillin and cephalosporin biosynthesis.
Relevance
PAH is used commercially for production of semi-synthetic penicillins.
3D structures of penicillin acylase
Updated on 15-June-2016
