Priyanka Basak/Sandbox
From Proteopedia
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UreE is an essential metallochaeprone for ''Helicobacter pylori'' (''H.pylori''). ''H.pylori'' is a class I human pathogen that is involved in causing gastric ulcers and stomach cancers. Its two nickel dependent enzymes - Urease and NiFe-H2ase, provides it a unique ability to survive and colonize in acidic human stomach. Urease catalyzes the conversion of urea to ammonia and carbamate which neutralizes its local acidic environment. | UreE is an essential metallochaeprone for ''Helicobacter pylori'' (''H.pylori''). ''H.pylori'' is a class I human pathogen that is involved in causing gastric ulcers and stomach cancers. Its two nickel dependent enzymes - Urease and NiFe-H2ase, provides it a unique ability to survive and colonize in acidic human stomach. Urease catalyzes the conversion of urea to ammonia and carbamate which neutralizes its local acidic environment. | ||
== Function == | == Function == | ||
| - | Several accessory proteins play a crucial role in the maturation of Urease. UreE is a urease-specific | + | Several accessory proteins play a crucial role in the maturation of Urease. UreE is a urease-specific nickel metallochaperone that is involved in the delivery nickel to urease. |
== Structural highlights == | == Structural highlights == | ||
| - | Apo-UreE from ''H.pylori'' is a dimer which becomes tetrameric (dimer of dimer) when bound to metal. ''Hp''UreE can bind one Ni(II) <scene name='60/609775/Nickel_bound_uree/5'>Nickel bound | + | Apo-UreE from ''H.pylori'' is a dimer which becomes tetrameric (dimer of dimer) when bound to metal. ''Hp''UreE can bind one Ni(II) <scene name='60/609775/Nickel_bound_uree/5'>Nickel bound UreE</scene>. Nickel is bound to UreE in an octahedral fashion with one His from one subunit and two His from other subunit <scene name='60/609775/Nickel_bound_uree_2/2'>(UreE-Nickel Binding site)</scene>. |
Revision as of 20:02, 2 December 2014
Introduction
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