Molecular Playground/UreE
From Proteopedia
(Difference between revisions)
(New page: ==Introduction== <StructureSection load='3tj8' size='340' side='right' caption='''Hp''UreE,PDB ID: 1TJ8 ' scene=''> UreE is an essential metallochaeprone for ''Helicobacter pylori'' (''H.p...) |
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==Introduction== | ==Introduction== | ||
| - | <StructureSection load='3tj8' size='340' side='right' caption='''Hp''UreE,PDB ID: | + | <StructureSection load='3tj8' size='340' side='right' caption='''Hp''UreE,PDB ID: [[1tj8]] ' scene=''> |
| - | UreE is an essential metallochaeprone for ''Helicobacter pylori'' (''H.pylori''). ''H.pylori'' is a class I human pathogen that is involved in causing gastric ulcers and stomach cancers. Its two nickel dependent enzymes - Urease and NiFe-H2ase, provides it a unique ability to survive and colonize in acidic human stomach. Urease catalyzes the conversion of urea to ammonia and carbamate which neutralizes its local acidic environment. | + | '''UreE''' is an essential metallochaeprone for ''Helicobacter pylori'' (''H.pylori''). ''H.pylori'' is a class I human pathogen that is involved in causing gastric ulcers and stomach cancers. Its two nickel dependent enzymes - Urease and NiFe-H2ase, provides it a unique ability to survive and colonize in acidic human stomach. Urease catalyzes the conversion of urea to ammonia and carbamate which neutralizes its local acidic environment. |
== Function == | == Function == | ||
Several accessory proteins play a crucial role in the maturation of Urease. UreE is a urease-specific nickel metallochaperone that is involved in the delivery nickel to urease. | Several accessory proteins play a crucial role in the maturation of Urease. UreE is a urease-specific nickel metallochaperone that is involved in the delivery nickel to urease. | ||
Revision as of 08:33, 30 December 2014
Introduction
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