4tz2
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tz2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tz2 RCSB], [http://www.ebi.ac.uk/pdbsum/4tz2 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tz2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tz2 RCSB], [http://www.ebi.ac.uk/pdbsum/4tz2 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 20:29, 25 December 2014
Fragment-Based Screening of the Bromodomain of ATAD2
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