1m8z
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1ib3|1ib3]], [[1ib2|1ib2]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m8z OCA], [http://www.ebi.ac.uk/pdbsum/1m8z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m8z RCSB]</span> | ||
}} | }} | ||
| Line 25: | Line 28: | ||
[[Category: Wang, X.]] | [[Category: Wang, X.]] | ||
[[Category: Zamore, P D.]] | [[Category: Zamore, P D.]] | ||
| - | [[Category: BME]] | ||
[[Category: puf domain]] | [[Category: puf domain]] | ||
[[Category: pumilio homology domain]] | [[Category: pumilio homology domain]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:12:57 2008'' |
Revision as of 19:12, 30 March 2008
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| , resolution 1.9Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Related: | 1ib3, 1ib2
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure Of A Pumilio-Homology Domain
Overview
Puf proteins regulate translation and mRNA stability by binding sequences in their target RNAs through the Pumilio homology domain (PUM-HD), which is characterized by eight tandem copies of a 36 amino acid motif, the PUM repeat. We have solved the structure of the PUM-HD from human Pumilio1 at 1.9 A resolution. The structure reveals that the eight PUM repeats correspond to eight copies of a single, repeated structural motif. The PUM repeats pack together to form a right-handed superhelix that approximates a half doughnut. The distribution of side chains on the inner and outer faces of this half doughnut suggests that the inner face of the PUM-HD binds RNA while the outer face interacts with proteins such as Nanos, Brain Tumor, and cytoplasmic polyadenylation element binding protein.
About this Structure
1M8Z is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1IB3. Full crystallographic information is available from OCA.
Reference
Crystal structure of a Pumilio homology domain., Wang X, Zamore PD, Hall TM, Mol Cell. 2001 Apr;7(4):855-65. PMID:11336708
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