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3fk2
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fk2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fk2 RCSB], [http://www.ebi.ac.uk/pdbsum/3fk2 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fk2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fk2 RCSB], [http://www.ebi.ac.uk/pdbsum/3fk2 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GRLF1_HUMAN GRLF1_HUMAN]] Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor.<ref>PMID:1894621</ref> <ref>PMID:11054565</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 07:58, 24 December 2014
Crystal structure of the RhoGAP domain of human glucocorticoid receptor DNA-binding factor 1
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Categories: Homo sapiens | Arrowsmith, C H | Bochkarev, A | Bountra, C | Edwards, A M | Loppnau, P | Nedyalkova, L | Park, H | Structural genomic | Tempel, W | Tong, Y | Weigelt, J | Anti-oncogene | Cell cycle | Dna-binding | Gtpase activation | Gtpase-activating protein | Hydrolase activator | Nucleus | Phosphoprotein | Repressor | Sgc | Signaling protein | Transcription | Transcription regulation
