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Pyruvate dehydrogenase kinase
From Proteopedia
| Line 28: | Line 28: | ||
**[[2bu7]] - hPDK2 + acetamide derivative<br /> | **[[2bu7]] - hPDK2 + acetamide derivative<br /> | ||
**[[2bu8]] - hPDK2 + dichloro-acetic acid + ADP<BR /> | **[[2bu8]] - hPDK2 + dichloro-acetic acid + ADP<BR /> | ||
| - | **[[4mp2]], [[4mp7]], [[4mpc]], [[4mpe]], [[4mpn]] | + | **[[4mp2]], [[4mp7]], [[4mpc]], [[4mpe]], [[4mpn]], [[4v25]], [[4v26]] – hPDK2 + inhibitor<br /> |
| - | **[[3crk]], [[3crl]] – hPDK2 + | + | **[[3crk]], [[3crl]] – hPDK2 + pyruvate dehydrogenase E2 |
*PDK isozyme 3 | *PDK isozyme 3 | ||
Revision as of 08:07, 26 May 2015
Pyruvate dehydrogenase kinase (PDK) is part of the pyruvate dehydrogenase complex. This complex is located in the mitochondria and converts pyruvate to acetyl-CoA as part of the citric acid cycle. PDK phosphphorylates serine residues on pyruvate dehydrogenase using ATP. There are 4 isozymes of PDK. The isozymes differ in length, activity and phosphorylation sites.
3D structures of pyruvate dehydrogenase kinase
Updated on 26-May-2015
