3gsl
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gsl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gsl RCSB], [http://www.ebi.ac.uk/pdbsum/3gsl PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gsl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gsl RCSB], [http://www.ebi.ac.uk/pdbsum/3gsl PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 14:52, 25 December 2014
Crystal structure of PSD-95 tandem PDZ domains 1 and 2
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Categories: Rattus norvegicus | Imperiali, B | Olivier, N B | Sainlos, M | Cell junction | Cell membrane | Dlg4 | Glur6 | Lipoprotein | Membrane | Palmitate | Pdz domain | Phosphoprotein | Postsynaptic cell membrane | Psd-95 | Sap-90 | Sh3 domain | Structural protein | Synapse | Tandem
