This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3h44
From Proteopedia
(Difference between revisions)
| Line 8: | Line 8: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h44 RCSB], [http://www.ebi.ac.uk/pdbsum/3h44 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h44 RCSB], [http://www.ebi.ac.uk/pdbsum/3h44 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> [[http://www.uniprot.org/uniprot/CCL3_HUMAN CCL3_HUMAN]] Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).<ref>PMID:8525373</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 21: | Line 23: | ||
==See Also== | ==See Also== | ||
*[[Insulin-Degrading Enzyme|Insulin-Degrading Enzyme]] | *[[Insulin-Degrading Enzyme|Insulin-Degrading Enzyme]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 18:22, 25 December 2014
Crystal Structure of Insulin Degrading Enzyme in Complex with macrophage inflammatory protein 1 alpha
| |||||||||||
Categories: Homo sapiens | Insulysin | Guo, Q | Ren, M | Tang, W J | Chemotaxis | Cytokine | Disulfide bond | Hydrolase | Hydrolase-cytokine complex | Ide | Inflammatory response | Metal-binding | Metalloprotease | Mip1alpha | Protease | Secreted
