1ms7
From Proteopedia
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|PDB= 1ms7 |SIZE=350|CAPTION= <scene name='initialview01'>1ms7</scene>, resolution 1.97Å | |PDB= 1ms7 |SIZE=350|CAPTION= <scene name='initialview01'>1ms7</scene>, resolution 1.97Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=SHI:(S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC+ACID'>SHI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1ftj|1FTJ]], [[1ftk|1FTK]], [[1fto|1FTO]], [[1fwo|1FWO]], [[1ftm|1FTM]], [[1ftl|1FTL]], [[1gr2|1GR2]], [[1lb8|1LB8]], [[1lb9|1LB9]], [[1lbc|1LBC]], [[1m5e|1M5E]], [[1m5c|1M5C]], [[1m5d|1M5D]], [[1m5b|1M5B]], [[1m5f|1M5F]], [[1mm7|1MM7]], [[1mm6|1MM6]], [[1lbb|1LBB]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ms7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ms7 OCA], [http://www.ebi.ac.uk/pdbsum/1ms7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ms7 RCSB]</span> | ||
}} | }} | ||
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[[Category: Liljefors, T.]] | [[Category: Liljefors, T.]] | ||
[[Category: Lunn, M L.]] | [[Category: Lunn, M L.]] | ||
| - | [[Category: SHI]] | ||
| - | [[Category: ZN]] | ||
[[Category: agonist complex]] | [[Category: agonist complex]] | ||
[[Category: ionotropic glutamate receptor glur2]] | [[Category: ionotropic glutamate receptor glur2]] | ||
[[Category: ligand-binding core]] | [[Category: ligand-binding core]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:20:26 2008'' |
Revision as of 19:20, 30 March 2008
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| , resolution 1.97Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Related: | 1FTJ, 1FTK, 1FTO, 1FWO, 1FTM, 1FTL, 1GR2, 1LB8, 1LB9, 1LBC, 1M5E, 1M5C, 1M5D, 1M5B, 1M5F, 1MM7, 1MM6, 1LBB
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.97 A resolution, Crystallization in the presence of zinc acetate
Overview
X-ray structures of the GluR2 ligand-binding core in complex with (S)-Des-Me-AMPA and in the presence and absence of zinc ions have been determined. (S)-Des-Me-AMPA, which is devoid of a substituent in the 5-position of the isoxazolol ring, only has limited interactions with the partly hydrophobic pocket of the ligand-binding site, and adopts an AMPA-like binding mode. The structures, in comparison with other agonist complex structures, disclose the relative importance of the isoxazolol ring and of the substituent in the 5-position for the mode of binding. A relationship appears to exist between the extent of interaction of the ligand with the hydrophobic pocket and the affinity of the ligand.
About this Structure
1MS7 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
GluR2 ligand-binding core complexes: importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists., Kasper C, Lunn ML, Liljefors T, Gouaux E, Egebjerg J, Kastrup JS, FEBS Lett. 2002 Nov 6;531(2):173-8. PMID:12417307
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