1mup
From Proteopedia
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|PDB= 1mup |SIZE=350|CAPTION= <scene name='initialview01'>1mup</scene>, resolution 2.4Å | |PDB= 1mup |SIZE=350|CAPTION= <scene name='initialview01'>1mup</scene>, resolution 2.4Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene> | + | |LIGAND= <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=TZL:2-(SEC-BUTYL)THIAZOLE'>TZL</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mup OCA], [http://www.ebi.ac.uk/pdbsum/1mup PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mup RCSB]</span> | ||
}} | }} | ||
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[[Category: North, A C.T.]] | [[Category: North, A C.T.]] | ||
[[Category: Phillips, S E.V.]] | [[Category: Phillips, S E.V.]] | ||
| - | [[Category: CD]] | ||
| - | [[Category: TZL]] | ||
[[Category: pheromone-binding]] | [[Category: pheromone-binding]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:21:21 2008'' |
Revision as of 19:21, 30 March 2008
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| , resolution 2.4Å | |||||||
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| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
PHEROMONE BINDING TO TWO RODENT URINARY PROTEINS REVEALED BY X-RAY CRYSTALLOGRAPHY
Overview
The principal protein excreted in male rat urine, urinary alpha 2-globulin and the homologous mouse protein, major urinary protein, have been well characterized, although their functions remain unclear. Male rat urine affects the behaviour and sexual response of female rats, leading to the proposal that rodent urinary proteins are responsible for binding pheromones and their subsequent release from drying urine. Urinary alpha 2-globulin is also involved in hyaline droplet nephropathy, an important toxicological syndrome in male rats resulting from exposure to a number of industrial chemicals and characterized by the accumulation of liganded urinary alpha 2-globulin in lysosomes in the kidney, followed by the induction of renal cancer. We now report the three-dimensional structures of mouse major urinary protein (at 2.4 A resolution) and rat urinary alpha 2-globulin (at 2.8 A resolution). The results corroborate the role of these proteins in pheromone transport and elaborate the structural basis of ligand binding.
About this Structure
1MUP is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography., Bocskei Z, Groom CR, Flower DR, Wright CE, Phillips SE, Cavaggioni A, Findlay JB, North AC, Nature. 1992 Nov 12;360(6400):186-8. PMID:1279439
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