3llr
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3llr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3llr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3llr RCSB], [http://www.ebi.ac.uk/pdbsum/3llr PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3llr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3llr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3llr RCSB], [http://www.ebi.ac.uk/pdbsum/3llr PDBsum]</span></td></tr> | ||
</table> | </table> | ||
+ | == Function == | ||
+ | [[http://www.uniprot.org/uniprot/DNM3A_HUMAN DNM3A_HUMAN]] Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity (By similarity).<ref>PMID:16357870</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] |
Revision as of 22:48, 25 December 2014
Crystal structure of the PWWP domain of Human DNA (cytosine-5-)-methyltransferase 3 alpha
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Categories: Homo sapiens | Arrowsmith, C H | Boutra, C | Dombrovski, L | Edwards, A M | Min, J | Ni, S | Qiu, W | Structural genomic | Weigelt, J | Wu, H | Alternative promoter usage | Chromatin regulator | Dna methyltransferase | Dna-binding | Metal-binding | Methyltransferase | Methylysine binding | Nucleus | Phosphoprotein | Repressor | S-adenosyl-l-methionine | Sgc | Transferase | Zinc-finger