1n66
From Proteopedia
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|PDB= 1n66 |SIZE=350|CAPTION= <scene name='initialview01'>1n66</scene> | |PDB= 1n66 |SIZE=350|CAPTION= <scene name='initialview01'>1n66</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[255d|255D]], [[1zif|1ZIF]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n66 OCA], [http://www.ebi.ac.uk/pdbsum/1n66 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n66 RCSB]</span> | ||
}} | }} | ||
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[[Category: rna internal loop]] | [[Category: rna internal loop]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:25:57 2008'' |
Revision as of 19:25, 30 March 2008
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| Ligands: | , , , | ||||||
| Related: | 255D, 1ZIF
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of the pyrimidine-rich internal loop in the Y-domain of poliovirus 3'UTR
Overview
Formation of non-canonical base-pairs in RNA often plays a very important functional role. In addition they frequently serve as factors in stabilizing the secondary structure elements that provide the frame of large compact RNA structures. Here we describe the structure of an internal loop containing a 5'CU3'/5'UU3' non-canonical tandem base-pair motif, which is conserved within the 3'-UTR of poliovirus-like enteroviruses. Structural details reveal striking regularities of the local helix geometry, resulting from alternating geometrical adjustments, which are important for understanding and predicting stabilities and configurations of tandem non-canonical base-pairs. The C-U and U-U base-pairs severely contract the minor groove of the sugar-phosphate backbone, which might be important for protein recognition or binding to other RNA elements.
About this Structure
1N66 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Structure of the pyrimidine-rich internal loop in the poliovirus 3'-UTR: the importance of maintaining pseudo-2-fold symmetry in RNA helices containing two adjacent non-canonical base-pairs., Lescrinier EM, Tessari M, van Kuppeveld FJ, Melchers WJ, Hilbers CW, Heus HA, J Mol Biol. 2003 Aug 22;331(4):759-69. PMID:12909008
Page seeded by OCA on Sun Mar 30 22:25:57 2008
