1n7d
From Proteopedia
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|PDB= 1n7d |SIZE=350|CAPTION= <scene name='initialview01'>1n7d</scene>, resolution 3.70Å | |PDB= 1n7d |SIZE=350|CAPTION= <scene name='initialview01'>1n7d</scene>, resolution 3.70Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> | + | |LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=KEG:12-TUNGSTOPHOSPHATE'>KEG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= LDLR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= LDLR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n7d OCA], [http://www.ebi.ac.uk/pdbsum/1n7d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n7d RCSB]</span> | ||
}} | }} | ||
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[[Category: Ichtchenko, K.]] | [[Category: Ichtchenko, K.]] | ||
[[Category: Rudenko, G.]] | [[Category: Rudenko, G.]] | ||
| - | [[Category: CA]] | ||
| - | [[Category: KEG]] | ||
[[Category: cholesterol metabolism]] | [[Category: cholesterol metabolism]] | ||
[[Category: familial hypercholesterolemia]] | [[Category: familial hypercholesterolemia]] | ||
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[[Category: ldl-receptor]] | [[Category: ldl-receptor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:26:22 2008'' |
Revision as of 19:26, 30 March 2008
| |||||||
| , resolution 3.70Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , , | ||||||
| Gene: | LDLR (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Extracellular domain of the LDL receptor
Contents |
Overview
The low-density lipoprotein receptor mediates cholesterol homeostasis through endocytosis of lipoproteins. It discharges its ligand in the endosome at pH < 6. In the crystal structure at pH = 5.3, the ligand-binding domain (modules R2 to R7) folds back as an arc over the epidermal growth factor precursor homology domain (the modules A, B, beta propeller, and C). The modules R4 and R5, which are critical for lipoprotein binding, associate with the beta propeller via their calcium-binding loop. We propose a mechanism for lipoprotein release in the endosome whereby the beta propeller functions as an alternate substrate for the ligand-binding domain, binding in a calcium-dependent way and promoting lipoprotein release.
Disease
Known disease associated with this structure: Hypercholesterolemia, familial OMIM:[606945]
About this Structure
1N7D is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the LDL receptor extracellular domain at endosomal pH., Rudenko G, Henry L, Henderson K, Ichtchenko K, Brown MS, Goldstein JL, Deisenhofer J, Science. 2002 Dec 20;298(5602):2353-8. Epub 2002 Nov 29. PMID:12459547
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