1n8j
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= AhpC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=602 Salmonella typhimurium]) | |GENE= AhpC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=602 Salmonella typhimurium]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1kyg|1KYG]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n8j OCA], [http://www.ebi.ac.uk/pdbsum/1n8j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n8j RCSB]</span> | ||
}} | }} | ||
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[[Category: peroxiredoxin]] | [[Category: peroxiredoxin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:26:50 2008'' |
Revision as of 19:26, 30 March 2008
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| , resolution 2.17Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | AhpC (Salmonella typhimurium) | ||||||
| Related: | 1KYG
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of AhpC with Active Site Cysteine mutated to Serine (C46S)
Overview
Eukaryotic 2-Cys peroxiredoxins (2-Cys Prxs) not only act as antioxidants, but also appear to regulate hydrogen peroxide-mediated signal transduction. We show that bacterial 2-Cys Prxs are much less sensitive to oxidative inactivation than are eukaryotic 2-Cys Prxs. By identifying two sequence motifs unique to the sensitive 2-Cys Prxs and comparing the crystal structure of a bacterial 2-Cys Prx at 2.2 angstrom resolution with other Prx structures, we define the structural origins of sensitivity. We suggest this adaptation allows 2-Cys Prxs to act as floodgates, keeping resting levels of hydrogen peroxide low, while permitting higher levels during signal transduction.
About this Structure
1N8J is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.
Reference
Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling., Wood ZA, Poole LB, Karplus PA, Science. 2003 Apr 25;300(5619):650-3. PMID:12714747
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