3nvq
From Proteopedia
(Difference between revisions)
| Line 8: | Line 8: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nvq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nvq RCSB], [http://www.ebi.ac.uk/pdbsum/3nvq PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nvq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nvq RCSB], [http://www.ebi.ac.uk/pdbsum/3nvq PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SEM7A_HUMAN SEM7A_HUMAN]] Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.<ref>PMID:12879062</ref> <ref>PMID:17377534</ref> <ref>PMID:17671519</ref> [[http://www.uniprot.org/uniprot/PLXC1_HUMAN PLXC1_HUMAN]] Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity).<ref>PMID:20727575</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 18:17, 25 December 2014
Molecular mechanism of guidance cue recognition
| |||||||||||
