1nbr
From Proteopedia
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|PDB= 1nbr |SIZE=350|CAPTION= <scene name='initialview01'>1nbr</scene> | |PDB= 1nbr |SIZE=350|CAPTION= <scene name='initialview01'>1nbr</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1aqo|1AQO]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nbr OCA], [http://www.ebi.ac.uk/pdbsum/1nbr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nbr RCSB]</span> | ||
}} | }} | ||
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[[Category: translational regulation]] | [[Category: translational regulation]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:28:10 2008'' |
Revision as of 19:28, 30 March 2008
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| Ligands: | , , , | ||||||
| Related: | 1AQO
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Iron Responsive Element RNA Hairpin, NMR, 15 Structures
Overview
The iron-responsive element (IRE) is a 30nt RNA motif located in the non-coding regions of mRNAs of proteins involved in iron regulation. In humans, the IRE plays a direct role in the control of iron levels by post-transcriptional regulation of the ferritin and transferrin receptor proteins through highly specific recognition by IRE-binding proteins. The IRE fold is representative of many RNA motifs that contain helical domains separated by a bulge or internal loop. The global structures of such extended multi-domain RNAs are not well defined by conventional NMR-distance and torsion angle structural restraints. Residual dipolar couplings (RDCs) are employed here to better define the global structure of the IRE RNA in solution. RDCs contain valuable long-range structural information that compliments the short-range structural data derived from standard NOE-distance and torsion angle restraints. Several approaches for estimating alignment tensor parameters and incorporating RDCs into RNA structure determinations are compared. Both the local and global structure of the IRE are improved significantly by refinement with RDCs. These RDC refinements provide insight on the conformational dynamics of the IRE. These studies highlight some issues that need to be addressed when incorporating RDCs in solution structure determinations of nucleic acids. The approach used here should prove valuable for structure determinations of various multi-domain systems.
About this Structure
1NBR is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Refined solution structure of the iron-responsive element RNA using residual dipolar couplings., McCallum SA, Pardi A, J Mol Biol. 2003 Feb 28;326(4):1037-50. PMID:12589752
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