S100 protein
From Proteopedia
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**[[3c1v]], [[3cga]], [[3ko0]], [[4hsz]] – hCBP-4 + Ca <br /> | **[[3c1v]], [[3cga]], [[3ko0]], [[4hsz]] – hCBP-4 + Ca <br /> | ||
**[[3m0w]] – hCBP-4 + Ca + PCP<br /> | **[[3m0w]] – hCBP-4 + Ca + PCP<br /> | ||
| - | **[[3zwh]] – hCBP-4 (mutant) + Ca + myosin-9 peptide<br /> | + | **[[3zwh]], [[4cfq]], [[4cfr]] – hCBP-4 (mutant) + Ca + myosin-9 peptide<br /> |
**[[4eto]] – hCBP-4 + Ca + myosin-9 peptide<br /> | **[[4eto]] – hCBP-4 + Ca + myosin-9 peptide<br /> | ||
**[[2lnk]] – hCBP-4 + myosin-2a peptide - NMR<br /> | **[[2lnk]] – hCBP-4 + myosin-2a peptide - NMR<br /> | ||
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**[[1kso]], [[1k8u]], [[1k9p]] – hCBP-6 <br /> | **[[1kso]], [[1k8u]], [[1k9p]] – hCBP-6 <br /> | ||
**[[1k96]], [[1k9k]] – hCBP-6 + Ca <br /> | **[[1k96]], [[1k9k]] – hCBP-6 + Ca <br /> | ||
| + | **[[2m1k]] – hCBP-6 (mutant) + RAGE receptor - NMR <br /> | ||
| + | **[[4p2y]] – hCBP-6 + RAGE receptor + Ca + Zn <br /> | ||
*S100-A7 (Psoriasin) | *S100-A7 (Psoriasin) | ||
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**[[1xk4]] – hCBP-8 (mutant) + Ca + hCBP-9 (mutant) <br /> | **[[1xk4]] – hCBP-8 (mutant) + Ca + hCBP-9 (mutant) <br /> | ||
**[[4ggf]] – hCBP-8 + hCBP-9 + Ca + Mn <br /> | **[[4ggf]] – hCBP-8 + hCBP-9 + Ca + Mn <br /> | ||
| + | **[[4xgk]] – hCBP-8 (mutant) + hCBP-9 (mutant) + Ca + Mn <br /> | ||
*S100-A9 (Calgranulin-B or Migration inhibitory factor-related protein 14) | *S100-A9 (Calgranulin-B or Migration inhibitory factor-related protein 14) | ||
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**[[1mho]], [[3cr4]], [[3gk1]], [[3gk2]], [[3gk4]], [[3iqo]], [[3lk0]], [[3lk1]], [[3lle]], [[3rlz]] – bCBP + Ca <br /> | **[[1mho]], [[3cr4]], [[3gk1]], [[3gk2]], [[3gk4]], [[3iqo]], [[3lk0]], [[3lk1]], [[3lle]], [[3rlz]] – bCBP + Ca <br /> | ||
**[[3cr2]], [[3cr5]] – bCBP + Zn + Ca <br /> | **[[3cr2]], [[3cr5]] – bCBP + Zn + Ca <br /> | ||
| + | **[[4pdz]], [[4pe0]], [[4pe1]], [[4pe4]], [[4pe7]] – bCBP + Ca + inhibitor<br /> | ||
**[[4fqo]] – bCBP (mutant) + Ca + inhibitor<br /> | **[[4fqo]] – bCBP (mutant) + Ca + inhibitor<br /> | ||
**[[1uwo]], [[2pru]] – hCBP - NMR <br /> | **[[1uwo]], [[2pru]] – hCBP - NMR <br /> | ||
**[[2h61]], [[3hcm]] – hCBP + Ca <br /> | **[[2h61]], [[3hcm]] – hCBP + Ca <br /> | ||
| + | **[[4xyn]] – hCBP + Ca + RAGE peptide <br /> | ||
**[[3czt]], [[3d0y]], [[3d10]] – hCBP + Zn + Ca <br /> | **[[3czt]], [[3d0y]], [[3d10]] – hCBP + Zn + Ca <br /> | ||
**[[2m49]] – hCBP + fibroblast growth factor 2 - NMR<br /> | **[[2m49]] – hCBP + fibroblast growth factor 2 - NMR<br /> | ||
Revision as of 09:48, 14 June 2015
S100 proteins are calcium-binding proteins (CBP) found in vertebrates and contain 2 helix-loop-helix calcium binding sites. S100 name is derived from their being 100% soluble in ammonium sulfate. There are at least 21 S100 proteins. Most S100 proteins undergo conformational change upon calcium binding.
S100-A1 is a regulator of myocardial contractility.
S100-A2 may have a tumor suppression function.
S100-A4 and S100-A11 may function in motility, invasion and tubulin polymerization.
S100-A6 may function in calcium-dependent insulin release.
S100-A7 is an antimicrobial peptide mainly against E. coli.
S100-A8 combined with S100-A9 (calprotectin) may function in the inhibition of casein kinase and regulate inflammatory processes.
S100-A10 is implicated in the transport of neurotransmitters.
S100-A12 and S100-A13 may function in calcium-dependent signal transduction pathways.
S100-A15 is found in psoriatic skin and functions as antimicrobial peptide.
S100B levels increase in patients suffering from brain damage and are used as diagnostics for traumatic head injury.
S100G is vitamin-D dependent calcium-binding protein and is called calbindin D9k and calbindin D28k depending on its molecular weight. S100G mediates the transport of calcium across enterocytes.
3D Structures of S100 proteins
Updated on 14-June-2015
