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3raw
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3raw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3raw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3raw RCSB], [http://www.ebi.ac.uk/pdbsum/3raw PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3raw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3raw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3raw RCSB], [http://www.ebi.ac.uk/pdbsum/3raw PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CLK3_HUMAN CLK3_HUMAN]] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.<ref>PMID:9637771</ref> <ref>PMID:19168442</ref> | ||
==See Also== | ==See Also== | ||
*[[Dual specificity protein kinase|Dual specificity protein kinase]] | *[[Dual specificity protein kinase|Dual specificity protein kinase]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 18:54, 25 December 2014
Crystal Structure of human CDC-like kinase 3 isoform in complex with leucettine L41
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Categories: Dual-specificity kinase | Homo sapiens | Arrowsmith, C H | Bazureau, J P | Bountra, C | Bullock, A | Carreaux, F | Debdab, M | Delft, F von | Edwards, A M | Fedorov, O | Filippakopoulos, P | King, O | Knapp, S | Meijer, L | Muniz, J R.C | Renault, S | Structural genomic | Weigelt, J | Kinase | Nucleotide-binding | Serine/threonine-protein kinase | Sgc | Transferase | Tyrosine-protein kinase
