3r27
From Proteopedia
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==Crystal structure of the first RRM domain of heterogeneous nuclear ribonucleoprotein L (HnRNP L)== | ==Crystal structure of the first RRM domain of heterogeneous nuclear ribonucleoprotein L (HnRNP L)== | ||
<StructureSection load='3r27' size='340' side='right' caption='[[3r27]], [[Resolution|resolution]] 2.04Å' scene=''> | <StructureSection load='3r27' size='340' side='right' caption='[[3r27]], [[Resolution|resolution]] 2.04Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3r27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3r27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3R27 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HNRNPL, HNRPL, P/OKcl.14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HNRNPL, HNRPL, P/OKcl.14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3r27 RCSB], [http://www.ebi.ac.uk/pdbsum/3r27 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r27 OCA], [http://pdbe.org/3r27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3r27 RCSB], [http://www.ebi.ac.uk/pdbsum/3r27 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3r27 ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HNRPL_HUMAN HNRPL_HUMAN]] Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.<ref>PMID:11809897</ref> | ||
==See Also== | ==See Also== | ||
*[[Nucleoprotein|Nucleoprotein]] | *[[Nucleoprotein|Nucleoprotein]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Li, X]] | [[Category: Li, X]] | ||
[[Category: Liu, Y]] | [[Category: Liu, Y]] | ||
Revision as of 11:31, 10 December 2016
Crystal structure of the first RRM domain of heterogeneous nuclear ribonucleoprotein L (HnRNP L)
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