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1nth

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|PDB= 1nth |SIZE=350|CAPTION= <scene name='initialview01'>1nth</scene>, resolution 1.55&Aring;
|PDB= 1nth |SIZE=350|CAPTION= <scene name='initialview01'>1nth</scene>, resolution 1.55&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=BGX:4-METHYL-PYRROLINE-5-CARBOXYLIC ACID'>BGX</scene>
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|LIGAND= <scene name='pdbligand=BGX:4-METHYL-PYRROLINE-5-CARBOXYLIC+ACID'>BGX</scene>, <scene name='pdbligand=X:2&#39;-DEOXY-N7-(8,9-DIHYDRO-9-HYDROXY-10-DEHYDROXY-AFLATOXIN)GUANOSINE+MONOPHOSPHATE'>X</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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|DOMAIN=
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|RELATEDENTRY=[[1l2q|1L2Q]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nth OCA], [http://www.ebi.ac.uk/pdbsum/1nth PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nth RCSB]</span>
}}
}}
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[[Category: James, C M.]]
[[Category: James, C M.]]
[[Category: Krzycki, J A.]]
[[Category: Krzycki, J A.]]
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[[Category: BGX]]
 
[[Category: tim barrel]]
[[Category: tim barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:01:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:35:18 2008''

Revision as of 19:35, 30 March 2008

Image:1nth.gif


PDB ID 1nth

Drag the structure with the mouse to rotate
, resolution 1.55Å
Ligands: ,
Related: 1L2Q


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal structure of the methanosarcina barkeri monomethylamine methyltransferase (MTMB)


Overview

Genes encoding methanogenic methylamine methyltransferases all contain an in-frame amber (UAG) codon that is read through during translation. We have identified the UAG-encoded residue in a 1.55 angstrom resolution structure of the Methanosarcina barkeri monomethylamine methyltransferase (MtmB). This structure reveals a homohexamer comprised of individual subunits with a TIM barrel fold. The electron density for the UAG-encoded residue is distinct from any of the 21 natural amino acids. Instead it appears consistent with a lysine in amide-linkage to (4R,5R)-4-substituted-pyrroline-5-carboxylate. We suggest that this amino acid be named l-pyrrolysine.

About this Structure

1NTH is a Single protein structure of sequence from Methanosarcina barkeri. This structure supersedes the now removed PDB entry 1L2R. Full crystallographic information is available from OCA.

Reference

A new UAG-encoded residue in the structure of a methanogen methyltransferase., Hao B, Gong W, Ferguson TK, James CM, Krzycki JA, Chan MK, Science. 2002 May 24;296(5572):1462-6. PMID:12029132

Page seeded by OCA on Sun Mar 30 22:35:18 2008

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