3zvo

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==Crystal structure of the hybrid state of ribosome in complex with the guanosine triphosphatase release factor 3==
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#REDIRECT [[4v8o]] This PDB entry is obsolete and replaced by 4v8o
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<StructureSection load='3zvo' size='340' side='right' caption='[[3zvo]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3zvo]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZVO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zvp|3zvp]], [[1dk1|1dk1]], [[1ibk|1ibk]], [[1f7y|1f7y]], [[1lou|1lou]], [[1ibl|1ibl]], [[2uuc|2uuc]], [[2wdk|2wdk]], [[2y0u|2y0u]], [[1kuq|1kuq]], [[1ab3|1ab3]], [[2j02|2j02]], [[1qjh|1qjh]], [[1j5e|1j5e]], [[2wrq|2wrq]], [[1hnx|1hnx]], [[2j00|2j00]], [[2b9o|2b9o]], [[2x9t|2x9t]], [[2uub|2uub]], [[2wh3|2wh3]], [[2xqd|2xqd]], [[1mvr|1mvr]], [[1cqn|1cqn]], [[1emw|1emw]], [[2v46|2v46]], [[1pnx|1pnx]], [[1qkf|1qkf]], [[1qkh|1qkh]], [[2vqf|2vqf]], [[2y10|2y10]], [[2wh1|2wh1]], [[1n32|1n32]], [[2y18|2y18]], [[2y12|2y12]], [[2wrn|2wrn]], [[2f4v|2f4v]], [[1twt|1twt]], [[2uxd|2uxd]], [[1fka|1fka]], [[1fjg|1fjg]], [[1n36|1n36]], [[2uxc|2uxc]], [[1hnw|1hnw]], [[1l1u|1l1u]], [[1hr0|1hr0]], [[2v48|2v48]], [[2xuy|2xuy]], [[1an7|1an7]], [[2b64|2b64]], [[1xmq|1xmq]], [[2b9m|2b9m]], [[2wdg|2wdg]], [[1xnr|1xnr]], [[1hnz|1hnz]], [[2wdh|2wdh]], [[1jgq|1jgq]], [[1i94|1i94]], [[1cqm|1cqm]], [[2xsy|2xsy]], [[1i96|1i96]], [[2uu9|2uu9]], [[1eg0|1eg0]], [[1vox|1vox]], [[1ibm|1ibm]], [[2uxb|2uxb]], [[2vqe|2vqe]], [[1g1x|1g1x]], [[2bvz|2bvz]], [[1i95|1i95]], [[2uua|2uua]], [[1voz|1voz]], [[1xnq|1xnq]], [[2xfz|2xfz]], [[2bxj|2bxj]], [[1gix|1gix]], [[1jgo|1jgo]], [[1jgp|1jgp]], [[2xg1|2xg1]], [[2x9r|2x9r]], [[1n34|1n34]], [[2y0w|2y0w]], [[1n33|1n33]], [[2jl7|2jl7]], [[1pns|1pns]], [[1yl4|1yl4]], [[2y0y|2y0y]], [[1ris|1ris]], [[2wdm|2wdm]], [[1xmo|1xmo]], [[2y14|2y14]], [[1i97|1i97]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zvo RCSB], [http://www.ebi.ac.uk/pdbsum/3zvo PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Protein release factor 3 (RF3), a guanosine triphosphatase, binds to ribosome after release of the nascent peptide and promotes dissociation of the class I release factors during the termination of protein synthesis. Here we present the crystal structure of the 70S ribosome with RF3 in the presence of a nonhydrolyzable GTP analogue, guanosine 5'-beta,gamma-methylenetriphosphate (GDPCP), refined to 3.8 A resolution. The structure shows that the subunits of the ribosome are rotated relative to each other compared to the canonical state, resulting in a P/E hybrid state for the transfer RNA. The substantial conformational rearrangements in the complex are described and suggest how RF3, by stabilizing the hybrid state of the ribosome, facilitates the dissociation of class I release factors.
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Crystal structure of the hybrid state of ribosome in complex with the guanosine triphosphatase release factor 3.,Jin H, Kelley AC, Ramakrishnan V Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15798-803. Epub 2011 Sep 8. PMID:21903932<ref>PMID:21903932</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
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*[[Ribosomal protein THX|Ribosomal protein THX]]
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*[[Ribosome 3D structures|Ribosome 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Thermus thermophilus]]
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[[Category: Jin, H]]
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[[Category: Kelley, A C]]
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[[Category: Ramakrishnan, V]]
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[[Category: Guanosine triphosphatase]]
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[[Category: Hybrid state]]
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[[Category: P/e trna]]
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[[Category: Release factor 3]]
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[[Category: Ribosome]]
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Current revision

  1. REDIRECT 4v8o This PDB entry is obsolete and replaced by 4v8o

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