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4fva
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fva OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fva RCSB], [http://www.ebi.ac.uk/pdbsum/4fva PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fva OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fva RCSB], [http://www.ebi.ac.uk/pdbsum/4fva PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TYDP2_CAEEL TYDP2_CAEEL]] DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 17:38, 24 December 2014
Crystal structure of truncated Caenorhabditis elegans TDP2
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