4asx
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| + | |||
==Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a beta-carboline inhibitor== | ==Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a beta-carboline inhibitor== | ||
<StructureSection load='4asx' size='340' side='right' caption='[[4asx]], [[Resolution|resolution]] 2.05Å' scene=''> | <StructureSection load='4asx' size='340' side='right' caption='[[4asx]], [[Resolution|resolution]] 2.05Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4asx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[4asx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ASX FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6OJ:7,8-BIS(CHLORANYL)-9-METHYL-3,4-DIHYDRO-2H-PYRIDO[3,4-B]INDOL-1-ONE'>6OJ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6OJ:7,8-BIS(CHLORANYL)-9-METHYL-3,4-DIHYDRO-2H-PYRIDO[3,4-B]INDOL-1-ONE'>6OJ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein_serine/threonine_kinase Receptor protein serine/threonine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.30 2.7.11.30] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein_serine/threonine_kinase Receptor protein serine/threonine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.30 2.7.11.30] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4asx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4asx RCSB], [http://www.ebi.ac.uk/pdbsum/4asx PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4asx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asx OCA], [http://pdbe.org/4asx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4asx RCSB], [http://www.ebi.ac.uk/pdbsum/4asx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4asx ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AVR2A_HUMAN AVR2A_HUMAN]] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Receptor protein serine/threonine kinase]] | [[Category: Receptor protein serine/threonine kinase]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
Revision as of 02:42, 11 December 2016
Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a beta-carboline inhibitor
| |||||||||||
