1nz6
From Proteopedia
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|PDB= 1nz6 |SIZE=350|CAPTION= <scene name='initialview01'>1nz6</scene>, resolution 2.5Å | |PDB= 1nz6 |SIZE=350|CAPTION= <scene name='initialview01'>1nz6</scene>, resolution 2.5Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nz6 OCA], [http://www.ebi.ac.uk/pdbsum/1nz6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nz6 RCSB]</span> | ||
}} | }} | ||
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[[Category: anti-parallel helix hairpin]] | [[Category: anti-parallel helix hairpin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:37:37 2008'' |
Revision as of 19:37, 30 March 2008
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| , resolution 2.5Å | |||||||
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Auxilin J-Domain
Overview
J-domains are widespread protein interaction modules involved in recruiting and stimulating the activity of Hsp70 family chaperones. We have determined the crystal structure of the J-domain of auxilin, a protein which is involved in uncoating clathrin-coated vesicles. Comparison to the known structures of J-domains from four other proteins reveals that the auxilin J-domain is the most divergent of all J-domain structures described to date. In addition to the canonical J-domain features described previously, the auxilin J-domain contains an extra N-terminal helix and a long loop inserted between helices I and II. The latter loop extends the positively charged surface which forms the Hsc70 binding site, and is shown by directed mutagenesis and surface plasmon resonance to contain side chains important for binding to Hsc70.
About this Structure
1NZ6 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.
Reference
Structure-function analysis of the auxilin J-domain reveals an extended Hsc70 interaction interface., Jiang J, Taylor AB, Prasad K, Ishikawa-Brush Y, Hart PJ, Lafer EM, Sousa R, Biochemistry. 2003 May 20;42(19):5748-53. PMID:12741832
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