1o0l
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= BCL2L2 OR BCLW OR KIAA0271 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= BCL2L2 OR BCLW OR KIAA0271 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o0l OCA], [http://www.ebi.ac.uk/pdbsum/1o0l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1o0l RCSB]</span> | ||
}} | }} | ||
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[[Category: helical bundle]] | [[Category: helical bundle]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:38:06 2008'' |
Revision as of 19:38, 30 March 2008
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| Gene: | BCL2L2 OR BCLW OR KIAA0271 (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE STRUCTURE OF BCL-W REVEALS A ROLE FOR THE C-TERMINAL RESIDUES IN MODULATING BIOLOGICAL ACTIVITY
Overview
Pro-survival Bcl-2-related proteins, critical regulators of apoptosis, contain a hydrophobic groove targeted for binding by the BH3 domain of the pro-apoptotic BH3-only proteins. The solution structure of the pro-survival protein Bcl-w, presented here, reveals that the binding groove is not freely accessible as predicted by previous structures of pro-survival Bcl-2-like molecules. Unexpectedly, the groove appears to be occluded by the C-terminal residues. Binding and kinetic data suggest that the C-terminal residues of Bcl-w and Bcl-x(L) modulate pro-survival activity by regulating ligand access to the groove. Binding of the BH3-only proteins, critical for cell death initiation, is likely to displace the hydrophobic C-terminal region of Bcl-w and Bcl-x(L). Moreover, Bcl-w does not act only by sequestering the BH3-only proteins. There fore, pro-survival Bcl-2-like molecules probably control the activation of downstream effectors by a mechanism that remains to be elucidated.
About this Structure
1O0L is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity., Hinds MG, Lackmann M, Skea GL, Harrison PJ, Huang DC, Day CL, EMBO J. 2003 Apr 1;22(7):1497-507. PMID:12660157
Page seeded by OCA on Sun Mar 30 22:38:06 2008
Categories: Homo sapiens | Single protein | Day, C L. | Harrison, P J. | Hinds, M G. | Huang, D C.S. | Lackmann, M. | Skea, G L. | Apoptosis | Bcl-2 | Bh3 | Binding groove | Helical bundle
