4b4c
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b4c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b4c RCSB], [http://www.ebi.ac.uk/pdbsum/4b4c PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b4c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b4c RCSB], [http://www.ebi.ac.uk/pdbsum/4b4c PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CHD1_HUMAN CHD1_HUMAN]] ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.<ref>PMID:18042460</ref> | ||
==See Also== | ==See Also== | ||
*[[Chromodomain-helicase-DNA-binding protein|Chromodomain-helicase-DNA-binding protein]] | *[[Chromodomain-helicase-DNA-binding protein|Chromodomain-helicase-DNA-binding protein]] | ||
*[[Helicase|Helicase]] | *[[Helicase|Helicase]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 07:31, 25 December 2014
Crystal structure of the DNA-binding domain of human CHD1.
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Categories: DNA helicase | Homo sapiens | Allerston, C K | Arrowsmith, C H | Bountra, C | Burgess-Brown, N | Carpenter, E P | Cooper, C D.O | Edwards, A | Gileadi, F Von Delft O | Shrestha, L | Vollmar, M | Yue, W W | Chromatin regulation | Chromatin-remodeling | Chromodomain | Histone acetylation complex | Transcription
