4fte
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fte FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fte OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fte RCSB], [http://www.ebi.ac.uk/pdbsum/4fte PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fte FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fte OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fte RCSB], [http://www.ebi.ac.uk/pdbsum/4fte PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CAPSD_FHV CAPSD_FHV]] Capsid protein alpha self-assembles to form an icosahedral procapsid with a T=3 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins trimers. In addition, 240 calcium ions are incorporated per capsid during assembly. The capsid encapsulates the two genomic RNAs. Capsid maturation occurs via autoproteolytic cleavage of capsid protein alpha generating capsid protein beta and the membrane-active peptide gamma. Peptide gamma: membrane-permeabilizing peptide produced by virus maturation, thereby creating the infectious virion. After endocytosis into the host cell, peptide gamma is probably exposed in endosomes, where it permeabilizes the endosomal membrane, facilitating translocation of viral capsid or RNA into the cytoplasm (Probable). | ||
==See Also== | ==See Also== | ||
Revision as of 08:49, 25 December 2014
Crystal structure of the D75N mutant capsid of Flock House virus
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