4gzn
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gzn RCSB], [http://www.ebi.ac.uk/pdbsum/4gzn PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gzn RCSB], [http://www.ebi.ac.uk/pdbsum/4gzn PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ZFP57_MOUSE ZFP57_MOUSE]] Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element.<ref>PMID:15070898</ref> <ref>PMID:18854139</ref> <ref>PMID:23059534</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 16:55, 25 December 2014
Mouse ZFP57 zinc fingers in complex with methylated DNA
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