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4hld
From Proteopedia
(Difference between revisions)
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==Sulfonylpiperidines as Novel, Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase (TMK): Compound 11== | ==Sulfonylpiperidines as Novel, Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase (TMK): Compound 11== | ||
<StructureSection load='4hld' size='340' side='right' caption='[[4hld]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='4hld' size='340' side='right' caption='[[4hld]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4hld]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[4hld]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staar Staar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HLD FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=16T:1-[(3S)-1-{[3-(3-CHLOROPHENOXY)-4-HYDROXYPHENYL]SULFONYL}PIPERIDIN-3-YL]-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE'>16T</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=16T:1-[(3S)-1-{[3-(3-CHLOROPHENOXY)-4-HYDROXYPHENYL]SULFONYL}PIPERIDIN-3-YL]-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE'>16T</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gfd|4gfd]], [[4hdc|4hdc]], [[4gsy|4gsy]], [[4hej|4hej]], [[4hlc|4hlc]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gfd|4gfd]], [[4hdc|4hdc]], [[4gsy|4gsy]], [[4hej|4hej]], [[4hlc|4hlc]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SAR0483, tmk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=282458 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SAR0483, tmk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=282458 STAAR])</td></tr> |
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hld OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hld RCSB], [http://www.ebi.ac.uk/pdbsum/4hld PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hld OCA], [http://pdbe.org/4hld PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hld RCSB], [http://www.ebi.ac.uk/pdbsum/4hld PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hld ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KTHY_STAAR KTHY_STAAR]] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4hld" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| + | *[[Student Project 8 for UMass Chemistry 423 Spring 2015|Student Project 8 for UMass Chemistry 423 Spring 2015]] | ||
*[[Thymidylate kinase|Thymidylate kinase]] | *[[Thymidylate kinase|Thymidylate kinase]] | ||
== References == | == References == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Staar]] |
[[Category: DTMP kinase]] | [[Category: DTMP kinase]] | ||
[[Category: Olivier, N]] | [[Category: Olivier, N]] | ||
Revision as of 19:59, 15 December 2016
Sulfonylpiperidines as Novel, Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase (TMK): Compound 11
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