1od1
From Proteopedia
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|PDB= 1od1 |SIZE=350|CAPTION= <scene name='initialview01'>1od1</scene>, resolution 1.37Å | |PDB= 1od1 |SIZE=350|CAPTION= <scene name='initialview01'>1od1</scene>, resolution 1.37Å | ||
|SITE= <scene name='pdbsite=CAT:Catalytic+Aspartates'>CAT</scene> | |SITE= <scene name='pdbsite=CAT:Catalytic+Aspartates'>CAT</scene> | ||
| - | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | + | |LIGAND= <scene name='pdbligand=CHF:CYCLOHEXYLFLUOROSTATONE'>CHF</scene>, <scene name='pdbligand=DPH:DEAMINO-METHYL-PHENYLALANINE'>DPH</scene>, <scene name='pdbligand=EMR:N-AMINOETHYLMORPHOLINE'>EMR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TSM:2-HYDROSULFONYL-2-METHYLPROPANE'>TSM</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Endothiapepsin Endothiapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.22 3.4.23.22] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Endothiapepsin Endothiapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.22 3.4.23.22] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1od1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1od1 OCA], [http://www.ebi.ac.uk/pdbsum/1od1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1od1 RCSB]</span> | ||
}} | }} | ||
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[[Category: Mall, S.]] | [[Category: Mall, S.]] | ||
[[Category: Wood, S P.]] | [[Category: Wood, S P.]] | ||
| - | [[Category: | + | [[Category: hydrolase,acid proteinase,inhibitor,aspartyl protease]] |
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:43:27 2008'' |
Revision as of 19:43, 30 March 2008
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| , resolution 1.37Å | |||||||
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| Sites: | |||||||
| Ligands: | , , , , | ||||||
| Activity: | Endothiapepsin, with EC number 3.4.23.22 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
ENDOTHIAPEPSIN PD135,040 COMPLEX
Overview
The crystal structure of endothiapepsin complexed with the gem-diol inhibitor PD-135,040 has been anisotropically refined to a resolution of 1.37 A. The structure of this inhibitor complex is in agreement with previous structures of endothiapepsin gem-diol inhibitor complexes that have been used to develop proposed catalytic mechanisms. However, the increase in resolution over previous structures confirms the presence of a number of short hydrogen bonds within the active site that are likely to play an important role in the catalytic mechanism. The presence of low-barrier hydrogen bonds was indicated in a previous one-dimensional H NMR spectrum.
About this Structure
1OD1 is a Protein complex structure of sequences from Cryphonectria parasitica. Full crystallographic information is available from OCA.
Reference
The structure of endothiapepsin complexed with the gem-diol inhibitor PD-135,040 at 1.37 A., Coates L, Erskine PT, Mall S, Williams PA, Gill RS, Wood SP, Cooper JB, Acta Crystallogr D Biol Crystallogr. 2003 Jun;59(Pt 6):978-81. Epub 2003, May 23. PMID:12777758
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